慢性乙型肝炎患者肝功能、血清HBVDNA水平与肝脏病理相关性研究

Study on Correlation Between Hepatic Pathohistology and Liver Function or Serum HBV DNA in Patients with Chronic Hepatitis B

【目的】探讨慢性乙型肝炎患者肝功能、血清HBVDNA水平与肝炎活动度、肝纤维化分期的关系。【方法】对80例慢性乙肝患者和40例健康者,采用酶法检测肝功能血清指标ALT、AST、GGT,使用PCR技术测定HBVDNA含量,并与患者的肝组织病理学检查作对比。运用SPSS13.0软件进行组间比较、相关分析。【结果】随着肝组织炎症活动度和肝纤维化程度的增高,血清ALT、AST、GGT显著升高(P<0.01),病例组炎症各级、纤维化各期均显著高于对照组(P<0.01),G3与G4、S3与S4比较差异无显著性(P>0.05)。HBVDNA水平各组间比较(不包含对照组)差异无显著性(P>0.05)。【结论】血清ALT、AST、GGT是评价肝脏病理学改变的敏感指标,HBVDNA水平仅可作为肝病严重的参考指标。

[Objective]To explore relationship between liver inflammation activity or fibrosis stages and liver function or serum HBVDNA in patients with chronic hepatitis B （CHB）. [Methods]Towards 80 cases with CHB and 40 good health people, enzymaic method was used to detect liver function serum ALT,AST and GGT, and PCR technique was applied to examine the level of HBVDNA, meanwhile compared with hepatic histopathology. SPSS13.0 was carried into interclass comparison and correlation analysis. [Results]With hepatic tissue inflammation activity and hepatic fibrosis degree increasing, serum indexes ALT, AST, GGT raised significantly （ P 〈0. 01）. Their values in each inflammation ranks and liver fibrosis in patient group were significantly higher than those in control group （ P 〈0.01）. There was no significant difference between G3 and G4, S3 and S4（ P 〉0.05） . There was also no significant difference about HBVDNA level in each group （not including control group） （ P 〉0.05）. [Conclusion]Serum ALT, AST and GGT are sensitive indexes for evaluating liver pathological changes, but the level of HBVDNA only serve as reference indexes of severity of liver disease.