LEEP术治疗宫颈上皮内瘤样变76例临床研究

Clinical Research on the Treatment of 76 Patients with Cervical Intraepithelial Neoplasia by LEEP

【目的】探讨高频电波刀(LEEP)治疗宫颈上皮内瘤样病变(CIN)的临床效果及副作用。【方法】宫颈上皮内瘤样病变76例患者,采用LEEP治疗,切除组织送病理检查;并进行随访,对术后患者的病灶持续存在和复发等情况进行总结。【结果】6个月总治愈率为91.1%(70/76),病变持续存在率2.63%(2/76),术后1年复发率为3.95%(3/76),2年时复发率为1.37%(1/76)。手术时间(14±0.5)min,术中出血(15±2.5)mL,术后宫颈修复时间(31.38±3.25)d,不良反应主要有感染、局部肿胀、疼痛等。【结论】LEEP对宫颈病变诊治有其特殊的优越性,但需长期随访,尤其是术后前2年。

[Objective]To investigate the effectiveness and side effects of loop electrosurgical excision procedure（LEEP） for the treatment of cervical intraepithelial neoplasia（CIN）. [Methods] Seventy six patients of CIN treated by LEEP were followed up in our department. The incidences of residual and the recurrence were reviewed prospectively. [Results] The total cure rate was 91.1% （70/76） after LEEP for first 6 months. The rate of residual was 2.63% （2/76）. Relapse rate was 3.95%（3/76） patients in the first year and 1.37%（1/ 76） in the second year. During operation, it took 14±0.5 minutes and lost 15±2.5 mL blood,and the recovery time for post-operation was 31.38±3.25d. There were adverse reactions such as infection, pain and local swell. [Conclusion] LEEP is a kind of effective and safe method for the treatment of CIN. But the patients need to be followed for a long time, especially in the first two years.