牛磺酸对铝致神经毒性的拮抗作用

Antagonism of Taurene on Aluminum-induced Neurotoxicity of Learning in Mice

探讨了牛磺酸对铝所导致的神经毒性有否拮抗作用.将昆明品系小鼠30只随机分为3组:模型组、对照组和实验组.模型组小鼠每天AlCl3灌胃,剂量为0.2 g/kg bw;对照组灌胃等量生理盐水;实验组的每天灌胃剂量为AlCl30.2 g/kg bw和牛磺酸0.1 g/kg bw.各组连续灌胃7 w,用穿梭箱和Y迷宫检测学习记忆能力,同时测定脑组织SOD活性.铝对小鼠的神经有毒性作用,可降低学习记忆能力,使脑组织SOD活性下降.而牛磺酸可改善上述症状,对铝致神经毒性有拮抗作用.

To explore whether the taurine can counteract neurotoxicity induced by aluminum. 30 kunming strain mice were divided into three groups randomly, model group, control group, and taurine-treated group. Model group received daily AlCl3 0.2g/kg bw, control group was given normal saline in the same quantity, and taurine-treated group obtained AlCl3 0.2g./kg bw plus taurine 0.1 g./kg bw for 7 weeks using intragastric garage. The ability of leaming and memory was evaluated by shuttle-box and Y-maze test, and the superoxide dismutase（SOD） activity in cerebral tissues also be determined. The ability of learning and the SOD activity were lower in model group than control group, but those impairments were reduced by intragastric administration of taurine. Taurine has a protective effect that should counteract impairments of learning from neurotoxicity of aluminum.