摘要
目的:观察自制中药制剂"抗衰灵胶囊"合多奈哌齐治疗阿尔茨海默氏病(AD)的临床疗效。方法:对AD患者257例分别用"抗衰灵胶囊"(治疗组)与盐酸多奈哌齐片(对照组)进行随机对照观察,疗程8周。结果:治疗后治疗组患者简明精神状态检查表(MMSE)、长谷川痴呆量表(HDS)评分均较治疗前明显增加;对治疗前后精神症状量表(PRS)评分及血液流变学指标变化的观察,在改善患者精神症状及某些血液流变学指标方面治疗组略优于对照组;日常生活能力量表(ADL)评分治疗前后无明显变化;治疗组显效率32.0%,有效率68.8%;对照组分别为34.4%和69.5%,两组比较,差异无统计学意义。结论:"抗衰灵胶囊"对轻、中度AD患者有良好治疗效果,且无严重不良反应,其改善大脑微循环作用可能是"抗衰灵胶囊"治疗AD的机制之一。
Objectlve：To observe the clinical curative effect of Kangshuailing capsule and Donepezil on treating Alzheimer disease （AD）. Methods：257 cases of AD were randomly divided into the treatment group and the contrast group. The treatment group was treated by Kangshuailing capsule and the contrast group by Donepezil respectively. The period of therapy was 8 weeks. Results： The scores of MMSE and HDS in the treatment group were obviously improved after therapy. The score of PRS and several index of blood rheology in the treatment group was better than that in the contrast group. The score of ADL had no obvious difference. The significant effective ratio and the effective ratio in the treatment group was 32.0% and 68.8% respectively. The significant effective ratio and the effective ratio in the contrast group was 34.4% and 69.5% respectively. There was no statistic meaning. Conclusion：Kangshuailing capsule has good effect on treating mild and moderate AD and has no serious side effect. One of its mechanism maybe it can improve the microcirculation of brain.
出处
《浙江中西医结合杂志》
2007年第11期663-664,667,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
