猪源Cathelicidins抗菌肽家族的研究进展

Advances in the research of cathelicidins antimicrobial peptides from pig

Cathelicidins是一类在哺乳动物中发现的含有保守的cathelin区域的抗菌肽,是宿主防御系统的重要组成部分,具有广谱且强大的抗菌活性。文中综述了猪源Cathelicidins抗菌肽家族的基因组成、结构、抗菌活性、作用机制及应用前景。

Cathelicidins, a family of mammalian antimicrobial peptides that carry a highly conserved cathelin domain, are important components of host-defense immunity system. They exert a broad spectrum and potent antimicrobial activities. This review is aimed at providing a general overview of cathelicidins from pig, with emphasis on aspects such as biosynthesis genes, structural features, antimicrobial spectrum, and mechanism of action and application outlook.