淀粉基阴离子微球的制备

Study on synthesis of starch-based anion microspheres

以可溶性淀粉为原料,N’N-亚甲基双丙烯酰胺(MBAA)及环氧氯丙烷(ECH)为交联剂,先在反向悬浮体系中采用两步交联法制备了中性淀粉微球,再用K3P3O9与中性淀粉微球反应制得淀粉基阴离子微球。以微球的平均粒径为指标,利用扫描电镜(SEM)和光透式粒度分析仪对产物进行了表征。结果表明,反应时间为2.5 h,淀粉溶液浓度为15%,油相与水相的体积比为3∶1,MBAA用量为0.4 g,乳化剂用量为1.0 g时,微球平均粒径分布较为均一,粒径在65μm以下的微球占95.5%,球形圆整,表面粗糙多孔,可用作药物载体和吸附剂。

The neutral starch microspheres were synthesized from soluble starch in the system of inverse suspension through two steps of bonding, using N, N＇-methylenebisacrylamide and epichlorohydrin as crosslinker. The starch-based anion microspheres were made of neutral starch microspheres by the secondary reaction using K3 P3 09 as the crosslinking agent. The product was characterized by scanning electron microscopy （SEM） and granularity analyzer, the result showes that the concentration of starch solution is 15% ,the reaction time is 2.5 h ,oil and water phase volume ratio is 3 ： 1 ,the use level of N,N＇ -methylenebisacrylamide is 0.4 g,the use levcl of emulsifying agent is 1.0 g. The average particle size of microspheres （≤65 μm） is 95.5%, and also are round, rough and porous which can be used as a kind of drug-carrier and adsorbents.