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Bowman-Birk型大豆胰蛋白酶抑制剂研究进展 被引量：15

PROGRESS ON THE RESEARCH OF BOWMAN-BIRK SOYBEAN TRYPSIN INHIBITOR
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摘要 阐述Bowman-Birk型大豆胰蛋白酶抑制剂(BBI)的分子结构、作用机制,并对其在医药领域、饲料工业及植物抗虫害等方面的研究进展进行了综述和展望。 The paper reviewed the molecular structure and function mechanism of BBI,and summerised the application and research development of BBI in the field of medicine,feed industry, and plant disease resistance.
作者 王长良 张永忠 孙志刚
机构地区 东北农业大学理学院应用化学系 哈尔滨市金合兽药器械经销部
出处 《大豆科学》 CAS CSCD 北大核心 2007年第5期757-761,共5页 Soybean Science
基金 黑龙江省"十一五"重大科技攻关项目(GA068402-4) 大豆生物学教育部重点实验室主任基金项目(SB05A04)
关键词 大豆胰蛋白酶抑制剂 分子结构 作用机制 Soybean trypsin inhibitor Molecular structures Function mechanism
分类号 TQ123 [化学工程—无机化工]
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参考文献28

  • 1Brik Y.The Bowman-Birk inhibitor.Trypsin and chymotrypsin inhibitor from soybeans[J].Int J Pept Protein Res,1985,25(2):113-131.
  • 2Keopke J,Ermler U,warkentin E,et al.Crystal structure of cancer chemopreventive bowman-birk inhibitor in ternary complex with bovine trypsin at 2.3 angstrom resolution.structural basis of janus-heed serine protease inhibitor specficity[J].Journal of Molecular Biology,2000,298,477-491.
  • 3McBride J D,Waston E M,Brauer A B,et al.Peptide mimics of the Bowman-Birk inhibitor reactive site loop[J].biopolymers,2001,66(2):79-92.
  • 4Laskowski,Qasim M A.What can the structures of enzymeinhibitor complexes tell us about the structures of enzyme aubstrate complexes[J].Biochem biophys Acta,2000,1477:324-337.
  • 5Ware J H,Wan X S,Rubin H,et al.Soybean Bowman-Birk protease inhibitor is a highly effective inhibitor of human mast cell chymase[J].Arch Biochem Biophys,1997,344(1):133-138.
  • 6于颖慧,吴坤.大豆Bowman-Birk型胰蛋白酶抑制剂(BBI)研究进展[J].疾病控制杂志,2005,9(2):150-153. 被引量：7
  • 7Malkwicz S B,Mc Kenna W G,Vaughn D J,et al.Effects of Bowman-Birk inhibitor concentrate(BBlC)in patients with begin prostatic hyperplasia[J].Prostate,2001,48(1):16-28.
  • 8Armstrong W B,Kennedy A R,Wan X S,et al.Single-dose administration of Bowman-Birk inhibitor concentrate in patients with oral leukoplakia[J].Cancer Epidemiol Biomarker Prey,2000,9(1):43-47.
  • 9Wan X S,Ware J H,Zhang L,et al.Treatment with soybean derived Bowman-Birk inhibitor increase serum prostate-specific antigen concentration while suppressing growth of human prostate cancer xcnografts in nude mice[J].Nutr caneer,1999,33(2):174-177.
  • 10Dittmann K,Loffler H,Bamberg M,et al.Bowman-Birk proteinaae inhibitor(BBI)modulates radio sensitivity and radiation-induced differentiation of human fibroblasts in culture[J].Radiother Oncol,1995,34(2):137-143.

二级参考文献45

  • 1Ding D，J Tech Acoust，1992年，11卷，3期，41页
  • 2石彦国，大豆制品工艺学，1992年，101,131,132页
  • 3Lei M G，J Agric Food Chem，1981年，29卷，1196页
  • 4Liu T Y，The Role of Sulfur in Proteins，1977年，240页
  • 5Birk Y. The Bowman-Birk inhibitor. Typsin and chymotrypsininhibitor from sybeans [J]. Int J Pept Protein Res , 1985, 25(2): 113-131.
  • 6Brauer AB, Domingo GJ, Cooke RM, et al . A conserved cis peptide bond is necessary for the activity of Bowman-Birk inhibitor protein [J]. Biochemistry , 2002,41(34) : 10608-10615.
  • 7Ware JH, Wan XS, Rubin H, et al . Soybean Bowman-Birk protease inhibitor is a highly effective inhibitor of human mast cell chymase[J]. Arch Biochem Biophys , 1997,344(1) : 133-138.
  • 8Struthers BJ, MacDonald JR. Comparative inhibition of tryps insfrom .several species by soybean trypsin inhibitors [J ]. J Nutr ,1983,113(4) : 800-804.
  • 9Brandon DL, Bates AH, Friedman M. ELISA analysis of soybean trypsin inhibitors in processed foods[J]. Adv Exp Med Biol ,1991,289:321-337.
  • 10Billings PC, St clair WH, Maki PA. Distribution of the Bowman-Birk protease in hibitor in mice following oral administration [J].Cancer Lett , 1992,62(3) : 191-197.

共引文献33

同被引文献170

引证文献15

二级引证文献56

大豆科学
2007年 第5期

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