介入治疗前后肝癌肿瘤血管密度的X线解剖学研究

X-ray Anatomy of Vascular Density in Liver Cancer Tissue before and after Interventional Treatment

目的：探讨肿瘤血管密度与肝癌血管介入治疗的预后关系。方法：收集50例肝动脉造影资料，对其肝右叶肿瘤介入治疗前后进行观察。用计算机图像处理系统对其中43例肿瘤内外血管密度和肿瘤相对分布面积，进行X线解剖学测量。结果：介入治疗前肝动脉造影显示肝癌肿瘤区血管网增生／显著增生。介入治疗后肝癌癌肿区血管密度较治疗前明显减小（P〈0．05），以弥漫型癌肿减少更显著（P〈0．01）；肿瘤的相对面积缩小，弥漫型缩小的比率明显大于肿块型（P〈0．05）。结论：肝癌组织内血管密度值代表肝癌组织供血量的大小；对中晚期肝癌开展合理的介入治疗是进一步研究的课题。

Objective：To explore the relationship between the tumor vascular density and therapeutic effects of interventional treatment. Methods：The data of hepatic ateriography in 50 patients were collected before and after interventional treatment for tumors that in right lobe of liver. The X-ray anatomic measurements on the vascular density within and besides tumors, and the relative areas of tumors distribution, were carried out in 43 cases by computer image processing system. Results： The hepatic arteriography before interventional treatment demonstrated proliferation/remarkable proliferation of vessel nets in tumorous tissues. After interventional treatment, the vascular density in tumors decreased obviously （P 〈 0.05 ） , especially in the infiltrating type （P 〈0.01 ）. Meanwhile, the proportions of tumorous area in liver tissue were greatly reduced too （P 〈 0.05 ）. Conclusions：The vascular density presents the quantity of blood supply of liver cancer tissue. Interventional treatment for the middle or advanced stages of liver cancer is worth further studying.