慢性肾衰竭患者血清骨保护素浓度与心脏瓣膜钙化的关系

Serum osteoprotegerin levels are associated with the presence of valvular calcification in chronic renal failure patients

目的探讨慢性肾衰竭（CRF）患者血清骨保护素（OPG）水平与心脏瓣膜钙化的关系。方法以75例CRF患者[非透析组（ND）25例,腹透组（PD）28例,血透组（HD）22例1和10例健康人（对照组）为研究对象,采用酶联免疫复合物法测定患者血清OPG水平,分析其与心脏瓣膜钙化之间的关系。结果各组CRF患者血清中OPG水平[ND组（4.77±1.74）μg/L、PD组（5.22±1.57）μg/L、HD组（5.35±1.72）μg/L]显著高于对照组[（2.04±0.57）μg/L,P〈0.01]。OPG水平与年龄（r=0.311,P〈0.05）和C反应蛋白水平（r=0.353,P〈0.01）呈正相关。根据有无心脏瓣膜钙化分组后发现,存在瓣膜钙化的CRF患者OPG水平较无瓣膜钙化组显著升高[（6.28±1.66）μg/L比（4.59±1.40）μg/L,P〈0.01]。Logistic回归分析显示血清OPG水平是CRF患者心脏瓣膜钙化发生的一项独立危险因素（P〈0.01）。结论在CRF患者中,血清OPG水平与心脏瓣膜钙化相关。

Objective To elucidate the relationship between serum osteoprotegerin （OPG） levels and valvular calcification in chronic renal failure （CRF） patients. Methods The serum concentrations of OPG in 75 CRF patients and 10 age-matched controls were measured by ELISA. The presence of valvular calcification and its relationship with OPG levels were studied. Results Serum OPG levels in CRF patients [ND group （4.77±1.74） μg/L, PD group （5.22±1.57） μg/L, HD group（5.35±1.72） μg/L] were significantly higher than those in healthy controls [（2.04±0.57） μg/L, P〈0.01]. The concentration of OPG was positively correlated with age （r=0.311, P〈0.05） and C-reactive protein level （r=0.353, P〈0.01 ）. Compared to CRF patients without valvular calcification, OPG level in CRF patients with valvular calcification was significantly elevated [（6.28± 1.66） μg/L vs. （4.59±1.40） μg/L, P〈0.01]. Logistic regression analysis showed that OPG level was an independent factor of valvular calcification （P〈0.01）. Conclusion Serum OPG level is correlated with the presence of valvular calcification in CRF patients.