不同频率与强度差值对正常人错配负反应的影响

Effect of frequency difference and intensity difference on mismatch negativity change in normal persons

目的研究频率与强度的声学差异对正常人错配负反应(mismatch negativity,MMN)的影响。着重观察频率与强度的差异对正常人MMN潜伏期及幅度的影响以及可以引出MMN的声学差异的阈值。方法24例受试者纯音听力测试各个频率纯音听阈均在20dBHL以内。应用美国智听公司SmartEP听觉诱发电位仪测量MMN,观察频率与强度的差异对正常人MMN潜伏期及幅度的变化规律。结果随着频率差异或强度差异的减小,MMN潜伏期逐渐延长,MMN振幅逐渐降低。结论MMN图形稳定,是听觉分辨的客观神经生理检查的重要指标。

OBJECTIVE To study the effect of frequency difference and intensity difference on mismatch negativity （MMN） change in normal persons. Emphatically to observe the effect on the latency and amplitude of normal people＇s MMN, as well as the threshold of the acoustic difference which may induce the MMN. METHODS Twenty-four adults were included in this study. Their thresholds of pure tone audiometry were within 20dBHU The MMN were measured by using the Smart EP （ ear potentiometer provided by the company of Intelligent Hearing） and the rule of the change by the difference of frequency and intensity to the latency and amplitude of normal people＇s MMN were studied. RESULTS Along with the decreasing of the difference of the frequency, the MMN latency prolonged gradually. The amplitude of the MMN decreased gradually as the decreasing of the intensity difference. CONCLUSION A stable MMN graph is an important indicator of objective physiological test with hearing distinguish.