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基因表达系列分析及在移植耐受研究中的应用进展

Serial analysis of gene expression and its application in transplantation
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摘要 基因表达系列分析(SAGE)是一种能够快速、详细、准确地反映生物体内在不同的发育期及生理病理状态下基因表达水平的高效技术。SAGE 不需要已知基因序列,可以发现新的转录本,可以对组织、细胞进行基因表达的定量定性研究,在生物学及医学研究中得到了广泛的应用。 Serial analysis of gene expression （SAGE） is a powerful technique that can quickly and exactly refleet expression profile of genes in a given sample in different situations. SAGE does not require prior knowledge of the genes of interest. It can provide qualitative and quantitative data of every transcribed sequence in a particular cell or tissue type and find out novel genes. SAGE has been widely applied to analyzing gene expression in many biological and medical studies.
作者 王丹 候桂华
机构地区 山东大学医学院实验核医学研究所
出处 《国际免疫学杂志》 CAS 2007年第6期381-384,共4页 International Journal of Immunology
基金 国家自然科学基金(30471639)
关键词 基因表达系列分析 移植耐受 Serial analysis of gene expression Transplantation
分类号 R392-33 [医药卫生—免疫学]
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参考文献20

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二级参考文献20

  • 1Carmody IC,Meng L,Shen XD,et al.P-selectin knockout mice have improved outcomes with both warm ischemia and small bowel transplantation.Transplant Proc,2004,36 (2):263-264
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  • 6Cook-Mills JM,Johnson JD,Deem TL,et al.Calcium mobilization and Racl activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity.Biochem J,2004,378(Pt 2):539-547
  • 7Wang Q,Zhang M,Ding G,et al.Anti-ICAM-1 antibody and CTLA-4Ig synergistically enhance immature dendritic cells to induce donorspecific immune tolerance in vivo.Immunol Lett,2003,90(1):33-42
  • 8Larsson LC,Corbascio M,Pearson TC,et al.Induction of operational tolerance to discordant dopaminergic porcine xenografts.Transplantation,2003,75(9):1448-1454
  • 9Qian S,Wang Z,Lee Y,et al.Hepatocyte-induced apoptosis of activated T cells,a mechanism of liver transplant tolerance,is related to the expression of ICAM-1 and hepatic lectin.Transplant Proc,2001,33(1-2):226
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国际免疫学杂志
2007年 第6期

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