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移植免疫耐受中调节性T细胞的研究进展 被引量：5

The research progress of regulatory T cells in transplantation tolerance
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摘要 调节性 T 细胞(Tr)在诱导和维持移植免疫耐受过程中的作用越来越受到人们的重视。根据不同的细胞表型和功能已将 Tr 分为若干亚类,首先是胸腺内 T 细胞发育过程中自然产生的 CD4^+T细胞亚群,能够构成性表达 IL-2受体的α链(CD25)存在于外周,体内体外均可抑制效应性 T 细胞的增殖和功能;其次是产生于正常的免疫应答过程中的诱导性 Tr 亚群,包括 Tr1和 Th3通过分泌细胞因子如 IL-10和 TGF-β发挥抑制作用。除此之外,也有报道 CD8^+Tr、双阴性 T(DNT)细胞和 NK T 细胞在移植耐受的不同模型中亦发挥重要作用。因而研究各种 Tr 亚群的生物学特征、调节机制及其在移植耐受中的作用非常必要。 In the last decade there has been an increasing interest for the action of regulatory T cells （Treg） in preventing transplant rejection and maintaining transplant tolerance. Until now, numerous different Treg subsets have been identified that possess distinct phenotypes and functions in different transplantation models, including thymically derived CD4^＋ CD25^＋ Treg cells , type 1 T regulatoary （ Tr1 ） and Th3 cells, CD8^ ＋ Treg cells, DN T cells and NKT cells. This review will summarize the characteristics, mechanisms of action of these Treg subsets, as well as their role in transplant tolerance and their potential for therapy.
作者 徐佳 侯桂华
机构地区 山东大学医学院实验核医学研究所
出处 《国际免疫学杂志》 CAS 2007年第6期393-398,共6页 International Journal of Immunology
基金 国家自然科学基金资助(30471639)
关键词 调节性T细胞 移植 CD4^+ CD25^+ 调节性T细胞 Tr1 CD8^+ 调节性T细胞 DN T细胞 NK T细胞 Transplantation CD4^＋ CD25^＋ Treg cells Trl CD8^＋ Treg cells DN T
分类号 R392.4 [医药卫生—免疫学]
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参考文献20

  • 1Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity ,2005,22( 3 ) :329-341.
  • 2Banham AH. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3 ( + ) regulatory T cells. Trends Immunol, 2006,27 (12) :541-544.
  • 3Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nat Rev Immunol,2003,3 ( 3 ) :253-257.
  • 4蔡永君,孙文佶（审校）.固有CD4^+CD25^+调节性T细胞与其在移植耐受上的进展[J].国际免疫学杂志,2006,29(3):196-200. 被引量：2
  • 5Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4^+ CD25- naive T cells to CD4^+ CD25^+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med,2003,198 (12) :1875-1886.
  • 6Maile R, Pop SM, Tisch R, et. al. Low-avidity CD8loT cells induced by incomplete antigen stimulation in vivo regulate naive higher aviditxy CD8hi T cell responses to the same antigen. Eur J Immunol,2006,36 (2) :397-410.
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  • 8Chen W, Zhou D, Torrealba JR, et al. Donor Lymphocyte Infusion Induces Long-Term Donor-Specific Cardiac Xenograft Survival through Activation of Recipient Double-Negative Regulatory T Ceils. J Immunol,2005,175 (5) : 3409-3416.
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二级参考文献21

  • 1Taylor PA,Noelle RJ,Blazar BR.CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade.J Exp Med,2001,193(11):1311-1318.
  • 2Dieckmann D,Bruett CH,Ploettner H,et al.Human CD4(+)CD25(+) regulatory,contact-dependent T cells induce interleukin 10-producing,contact-independent type 1-like regulatory T cells.J Exp Med,2002,196(2):247-253.
  • 3Kataoka M,Margenthaler JA,Ku G,et al.Development of infectious tolerance after donor-specific transfusion and rat heart transplantation.J Immunol,2003,171(1):204-211.
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  • 5Graca L,Thompson S,Lin CY,et al.Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance.J Immunol,2002,168(11):5558-5565.
  • 6Hanash AM,Levy RB.Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation.Blood,2005,105(4):1828-1836.
  • 7Sakaguchi S.Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses.Annu Rev Immunol,2004,22:531-562.
  • 8Kataoka H,Takahashi S,Takase K,et al.CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4.Int Immunol,2005,17(4):421-427.
  • 9Fontenot JD,Gavin MA,Rudensky AY.Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.Nat Immunol,2003,4(4):330-336.
  • 10Khattri R,Cox T,Yasayko SA,et al.An essential role for Scurfin in CD4+CD25+ T regulatory cells.Nat Immunol,2003,4(4):337-342.

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二级引证文献7

国际免疫学杂志
2007年 第6期

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