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IL-18与类风湿性关节炎 被引量：1

Interleukin-18 and rheumatoid arthritis
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摘要 IL-18是一种多功能的炎性细胞因子,可强烈诱生 IFN-γ,加强 FasL 介导的细胞毒效应,具有重要的免疫调节功能。近年研究发现,IL-18有增强免疫、抗肿瘤等作用,同时也参与某些自身免疫病、变态反应性疾病的发生,如类风湿性关节炎,它通过多种途径诱导 IFN-γ产生,在类风湿性关节炎的发病机制中起着重要的作用。 Interleukin-18 （IL-18） is a kind of muhifunctional cytokine,it can induce strongly interferon gamma （IFN-γ） production . It plays an important role in immunoregulation . Recently investigations found that IL-18 can reinforce the immunity and play an important role in antitumour,and it may take part in the occurrence of some autoimmune diseases and allergic diseases , such as rheumatoid arthritis. It plays an important role in the pathogenesis of rheumatoid arthritis since its ability to induce IFN-γ production in many ways. This text will summarize the progress of the correlation of IL-18 and rheumatoid arthritis.
作者 任燕歌 黄宪章
机构地区 广东省中医院二沙岛分院检验科
出处 《国际免疫学杂志》 CAS 2007年第6期405-407,共3页 International Journal of Immunology
基金 广东省自然科学基金(04010056)
关键词 IL-18 细胞因子 IFN-Γ 类风湿性关节炎 Interleukin-18 Cytokine Gamma interferon Rheumatoid arthritis
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献18

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二级参考文献28

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共引文献11

同被引文献24

  • 1张临友,修殿辉,杨宝峰.Toll样受体与免疫排斥[J].国际免疫学杂志,2006,29(4):209-213. 被引量：2
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国际免疫学杂志
2007年 第6期

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