TLR9介导B细胞活化及其意义

Progress on B cell activation mediated by toll-like receptor 9

Toll 样受体(TLR)是固有免疫系统介导免疫识别的重要受体。随着研究的深入,TLR 被认为在适应性免疫中起着重要作用。新近研究显示,TLR 尤其是 TLR9可能直接介导 B 细胞活化,在抗体生成和类别转换过程中发挥重要作用,而不适当的 TLR 刺激则可能活化自身反应性 B 细胞,导致自身免疫性疾病。

Toll-like receptors （TLR） are not only essential for the innate immune system to recognize invacling microbes, but also considered to play an important role in adaptive immune response. Recently it was shown that TLR, especially TLRg, may directly mediate the activation of B cells and play a very important role in antibody response and class switch. However, inappropriate TLR signalling may activate self-reactive B cells thus leading to autoimmune diseases.