摘要
多发性硬化(MS)是以中枢神经系统炎性脱髓鞘为特征的自身免疫性疾病,神经功能障碍与髓鞘和轴索损伤有关。MS 动物模型研究认为:髓鞘修复是治疗 MS 极有前景的途径。中枢神经系统存在少突胶质细胞前体细胞(OPCs),在髓鞘修复和再生过程起关键作用。由于 MS 病人 OPC 分化受抑制,因此,在髓鞘再生过程中调控 OPCs 分化是髓鞘修复的重点。另外,移植外源性的髓鞘形成细胞促进髓鞘修复和神经再生,是修复 MS 脱髓鞘和轴索损伤的重要途径。
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by inflammation and demyelination. The neurological disability is associated with myelin and axon damage. Researches on animal model of MS indicated that remyelination appears to be one of the most feasible restoration strategies. The adult CNS contains oligodendrocyte precursor cells (OPC) that play a key role in myelin repair and remyelination. The differentiation of OPCs in MS is inhibited so that regulation of OPC differentiation during remyelination is critical to myelin repair. Besides, one possibility to achieve remyelination and subsequent restoration of neuronal function is to provide an exogenous source of myelinating cells via transplantation. This review focuses on concepts that are important for developing strategies of remyelination.
出处
《国际免疫学杂志》
CAS
2007年第6期439-443,共5页
International Journal of Immunology
基金
江苏省卫生厅科学基金项目(H200504)
关键词
多发性硬化
髓鞘修复
少突胶质细胞前体细胞
Multiple sclerosis
Myelin repair
Oligodendrocyte precursor cell (OPC)