用自制XZF液保存大鼠胰腺的实验研究

Experimental study on the preservation of pancreas with XZF solution in rat

我们采用乳果糖做为主要非渗透因子，加入磷酸盐缓冲液、组氨酸、谷眈甘肽等配制成一种新的等渗保存放—XZF液。将大鼠供胰腺以XZF液作低温灌洗保存12、18小时后行移植术。受体为糖尿病大鼠模型。胰腺保存12小时组，受体的移植物有功能存活一周以上达83％（5／6），保存18小时组为50％（4／8）。

A new cold solution-XZF solution, containing lactulose (as the main impermeable anions), phosphate (as the buffered solution), histidine and glutathione, was used. The experimental rat pancreas after preserved with cold XZF solution for 12 h was transplanted into the recipients with diabetes mellitus. The results showed that the functional survival rate over one week of the grafts through 12 h preservation was 83% (5/6) and 50% (4/8) through l8 h preservation,respectively.