胚胎牌细胞不同移植途径对小鼠接种性肉瘤生长和自然杀伤细胞活性的影响

Effects of sites of fetal spleen cell transplantation on the growth of transplanted tumor and natural Killer cells activity in mice

分别于肌肉、腹腔、周围静脉、门静脉对荷瘤小鼠移植胚胎牌细胞，并于移植后30天、60天分别测定瘤体积抑制率和自然杀伤细胞（NK细胞）活性。结果显示：上述4种移植途径在移植后30天均能明显抑制移植性肿瘤生长，NK细胞活性显著升高（P＜0．01）。但移植后60天，仅门静脉组对肿瘤生长保持良好的抑制状态，NK细胞活性保持较高水平，证明经门静脉移植是牌细胞移植最好的途径。

The fetal spleen cells were transplanted following the injection of S180 carcinosarcoma into the muscle, abdominal cavity, peripheral veins and portal vein in mice. The size inhibitory rate of the transplanted tumor and natural killer activity were evaluated 30 and 60 days after the injection. It was found that the growth of transplanted tumor was dramatically inhibited and natural killer activity was increased 30 days after the transplantation' But 60 days after the transplantation only portal venous transplanted tumor showed a satisfactory function of inhibiting tumor growth and natural killer activity maintained at a high level. These results indicated that portal vein was the best approach for the spleen cell transplantation