白芨甘露聚糖胶浆治疗上消化道出血的临床观察

Therapeutic effect of bletilla mannan on patients with upper gastrointestinal bleeding

目的观察白芨甘露聚糖胶浆对上消化道出血的疗效。方法将133例上消化道出血患者随机分为两组。观察组(73例)经胃管给予白芨甘露聚糖溶液(5%)50mL/4h;对照组(60例)经胃管给予凝血酶溶液1000u/4h。每4h抽取胃液查隐血,比较两组止血率和止血时间。结果观察组止血率(94.52%)与对照组(96.67%)相近(P>0.05);观察组总止血时间(31.37±16.54)h与对照组(36.89±19.64)h差异无显著性(P>0.05);但观察组对轻度出血患者的止血时间(21.58±13.67)h明显快于对照组(33.19±17.32)h(P<0.05);观察组用药前后患者的血小板记数、出血时间、凝血时间及凝血酶原时间无明显变化(P>0.05)。结论白芨甘露聚糖胶浆对上消化道出血有良好的止血疗效,其止血效果和止血时间与凝血酶相似,对全身凝血机能无影响,无明显不良反应。

[Objective] To study the clinical effects of bletilla mannan in treating upper gastrointestinal bleeding. [Methods] 133 patients with upper gastrointestinal bleeding were randomly divided into two groups. 73 patients in the treatment group were given bletilla mannan solution （5%） 50 mL/4 h by gastrogavage, and the other 60 patients in the control group were given thrombin solution 1000 u/4 h by gastrogavage. Gastric liquid was drawn every 4 hours for occult blood test. The hemostatic rate and time were compared between the two groups. [Results] In hemostatic rate, no significant difference existed between treatment group （94.52%） and control group （96.67%） （P 〉 0.05）. In the total hemostatic time, the difference between the two groups wasn＇t significant （P 〉0.05）. Among patients with light bleeding,the hemostatic time in treatment group （21.58±13.67） h was shorter than in control group （33.19±17.32） h （P 〈0.05）. [Conclusion] Bletilla mannan solution in treating upper gastrointestinal bleeding has good hemostatic effect, no adverse reactions. It does not interfere with coagulation on whole body.