31例抗生素相关性腹泻临床分析

31 case of clinical observation and analysis of antibiotic associated diarrhea

目的了解抗生素相关腹泻的临床特点、发病率、发病因素,提出预防控制措施。方法对31例抗生素相关腹泻患者的临床资料进行回顾性分析。结果抗生素相关腹泻的发生率为8.8%(31/352),与使用抗生素种类、联合用药数量及疗程、年龄等因素有关。引起抗生素相关腹泻的抗生素依次为广谱青霉素、第3代头孢菌素类、青霉素类、克林霉素、头孢二代、喹诺酮类。结论合理使用抗生素、控制广谱抗生素的应用,是预防控制医院感染抗生素相关腹泻的关键措施。

[ Objective ] To investigate the characteristics, the incidence, and relative factors of antibiotic associated diarrhea （AAD） in order to prevent and control it. [Methods] Retrospective analysis was performed in 31 patients with AAD. [Results] Prevalence ratio of AAD was 8.8% （31/352）, and the risk of AAD was related to the kinds of using mix antibiotics and period of treatment and age. The antibiotics causing AAD was extending penicillin or third cephalosporins, penicillin, carbapenemases, or second cephalosporins. [Conclusions] Rational use of antibiotic and limited use of antibiotic are the key measures to prevent and control AAD.