更昔洛韦治疗婴儿巨细胞病毒肝炎合并中枢协调障碍的疗效观察

Central coordination disturbance in cytomegalovirus hepatitis infants and the therapeutic effect of Ganciclovir on hepatitis

目的对更昔洛韦治疗婴儿巨细胞病毒肝炎合并中枢协调障碍的疗效和副作用进行评价。方法确诊的婴儿巨细胞病毒肝炎患儿,住院期间通过Vojta姿势发射结合肌张力检查筛选合并中枢协调障碍者。均给予更昔洛韦[总疗程6周5mg/(kg·次),每12h静滴1次,用2周后改每日1次]及综合治疗,疗程完成后评价脑损伤的恢复情况。结果80例婴儿巨细胞病毒肝炎患儿中极轻中枢协调障碍的有37.50%(30/80),轻度中枢协调障碍的18.75%(15/80),中度中枢协调障碍的7.50%(6/80),重度中枢协调障碍的3.75%0(3/80)。给予更昔洛韦及综合治疗后,脑损伤患儿部分恢复或症状有明显改善,前后比较差异有显著性。结论婴儿巨细胞病毒肝炎患儿合并有脑损伤的较多,应早期筛查以便及早作出干预措施。更昔洛韦治疗婴儿巨细胞病毒肝炎合并脑损伤患儿,可以促进脑损伤的恢复,副作用少。

[Objective] To describe the prevalence of central coordination disturbance in infants with cytomegalovirus hepatitis, and to evaluate the therapeutic and side effect of ganciclovir. [Methods] Vojta postural reflex and modified Ashworth scale was used to screening the children with central coordination disturbance before and after ganciclovir therapy （all patients are given ganciclovir 5 mg/kg weight/12 hour for 2 weeks, and 5 mg/kg weight/day for 4 weeks）. [Result] The prevalence of extra mild, mild, middle or serious Zentrale Koordinationsstorung （ZKS） in 80 CMV hepatitis infants were 37.50%（30/80）, 18.75%（15/80）, 7.50%（6/80） and 3.75% （3/80） respectively. The central coordination disturbance of patients was improved after ganciclovir therapy and no severe side effect was observed. [Conclusion] Central coordination disturbance was common in cytomegalovirus hepatitis children. Ganciclovir is a relative good and effective antivirus therapy on infant CMV hepatitis and it can also improve the recovery of central coordination disturbance with few side effects.