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BDNF Val66Met多态性与儿童智力的关联性研究

Association Study of BDNF Val66Met Polymorphism and Intelligence in Children
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摘要 目的研究脑神经营养因子（BDNF）Val66Met基因多态性与儿童智力的关系,为开展儿童智力的相关研究提供参考。方法以韦氏儿童智力量表（WISC-CR）测量115名6-16岁学龄儿童智商,采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）检测BD-NF Val66Met多态性,方差分析各基因型言语智商（VIQ）,操作智商（PIQ）和总智商（FIQ）之间的关联。结果女童VIQ和FIQ与BDNF Val66Met基因型有显著性关联,Met纯合子者得分显著高于Val纯合子;男童BDNF Val66Met与智商的关联无统计学意义。结论BDNF Val66Met基因多态性可能影响女童VIQ和FIQ。 Objective To explore the relationship between brain-derived neurotrophic factor（ BDNF） Val66Met and intelligence in children, and to provide evidence for the research of children＇s intelligence. Methods Totally 115 children aged 6 to 16 were collected to measure their IQ by WISC - CR and BDNF Val66Met pol.vmorphism by PCR - RFLP. The WISC - CR scale and IQ scores were coropared for individual genotypes using one-way analysis of variance. Results BDNF genotype was significantly associated with verbal IQ and full-scale IQ in girls, who with Met/Met genotype had a significantly higher mean than in Val/Val carriers. No significantly association was found between BDNF genotype and IQ scores in boys. Conclusion BDNF Va166Met pol.vroorphism may infulunce verbal IQ and full-scale IQ in girls.
作者 张悦 季成叶 甄宏 王莹 陈天娇
机构地区 北京大学儿童青少年卫生研究所
出处 《中国学校卫生》 CAS 北大核心 2007年第10期871-872,共2页 Chinese Journal of School Health
基金 国家自然科学基金项目"青春期发育调控机制影响因素的双生子研究"(编号:30371223)
关键词 多态性 限制性片断长度 脑源性神经营养因子 智力 对比研究 儿童 Polymorphism,restriction fragment length Brain-derived neurotrophic factor Intelligence Comparative study Child
分类号 R179 [医药卫生—妇幼卫生保健] R339.35 [医药卫生—人体生理学]
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参考文献12

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中国学校卫生
2007年 第10期

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