血尿酸水平与冠状动脉病变的相关性探讨

Research on correlation between uric acid and coronary artery disease

目的探讨血尿酸(UA)与冠状动脉病变累及范围、狭窄程度积分、斑快形态的相关性。方法检测80例不稳定心绞痛(UAP)、56例稳定性心绞痛(SAP)、32例急性心肌梗死(AMI)和72例对照组(无冠心病者)的血UA水平。所有患者均进行冠状动脉造影,采用Gensini积分评定冠脉狭窄程度,综合Ambrose及Lo等的分型方法将斑快分为I型、Ⅱ型和Ⅲ型。结果AMI组、UAP组和SAP组血UA水平显著高于对照组(P<0.01),各型斑块间的血UA水平无差异;冠脉单支、双支、三支病变患者血UA水平与对照组比较差异有统计学意义(P≤0.01),但单支、双支、三支病变患者间血UA水平比较差异无统计学意义。结论冠心病患者UA水平显著高于正常人,但与冠状动脉病变程度无关。

[ Objective] To study the correlation between serum uric acid（UA） and the range of coronary lesions, the severity of coronary stenosis score, the morphology of plague. [ Methods] The levels of UA in 80 patients with UAP, 32 patients with AMI, 56 patients with SAP and 72 controls （patients without coronary heart disease） were measured. All patients （with or without coronary heart disease） were performed coronary angiography. The severity of coronary stenosis was evaluated by using Gensini score methord. The plague was divided into type Ⅰ , type Ⅱ and type Ⅲ by using the method of Ambrose and Lo. [ Results] The levels of UA in AMI group, UAP group and SAP group were significantly higher than that of control group （ P 〈 0.01 ）. The UA levels of different plague typed had no significant difference. There were significant differences on the levels of UA between single vessel disease, two vessel disease, three vessel disease and controls（P 〈 0.01 ）. But no difference was found among three types of coronary artery diseases（P 〈 0.05 ）. [ Conclusion] The level of UA is higher in coronary disease, but it is not correlated with severity of coronary artery disease.