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PTP-1B基因突变的PCR-RFLP与肥胖的相关性 被引量：1

The relationship of the mutation-linked PCR-RFLP of protein tyrosine phosphatase 1B (PTP-1B)with obesity in Chinese
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摘要 采用多聚酶联反应-限制性片段长度多态性方法,对110例单纯肥胖者、110例肥胖合并2型糖尿病者、120例正常对照者PTP1B基因ISV5+3666、303位编码子进行酶切研究。结果显示PTP1B基因的P303P突变可能与肥胖发生相关,ISV5+3666delT突变与肥胖发生不相关。 ISV5 ＋ 3666delT and P303P polymorphisms of PTP-1B were determined by PCR-RFLP in 110 obese subjects, 110 obese diabetics and 120 control subjects. The results suggested that P303P, not ISV5 ＋ 3666delT, polymorphism of PTP-1B may relate to obesity in Chinese.
作者 方立本 邹大进 黄勤 刘连勇 王淼 赵琳
机构地区 第二军医大学附属长海医院内分泌代谢科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2007年第10期593-595,共3页 Chinese Journal of Diabetes
关键词 肥胖 基因 突变 蛋白酪氨酸磷酸酶1B Obesity Gene Mutation Protein tyrosine phosphatase 1 B
分类号 R589.2 [医药卫生—内分泌]
  • 相关文献

参考文献5

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二级参考文献10

  • 1Goldstein BJ, Bittner-Kowalczyk A, White MF, et al.Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem, 2000,275:4283-4289.
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共引文献1

同被引文献18

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中国糖尿病杂志
2007年 第10期

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