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糖代谢相关指标与PPARδ-87T/C基因多态性的关系研究 被引量：1

The relationship of some indices of glycometabolism with peroxisome proliferator-activated receptor delta polymorphism
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摘要 大连市人群中2型糖尿病(T2DM)194例,正常空腹血糖(NFG)127例,应用PCR基因扩增、限制性内切酶基因多态性方法,对PPAR-δ基因的-87位点T→C的变异,进行基因型和等位基因分析。发现T2DM与NFG两组间不存在基因型频度分布的明显差异。但是,T2DM组内的BMI呈现基因型之间的明显差异;NFG组内,HOMA-IR存在不同基因型之间的明显差异。 Cases with T2DM（ n = 194） and subjects with normal fasting plasma glucose （NFG, n = 127） were enrolled in population of Dalian city for the PCR-PFLP -detected PPAR delta gene -87T→C polymorphism and other clinical data collection. The results showed there were no differences in the distribution of genotypic frequencies between groups of T2DM and NFG（ P = 0. 99）. BMI showed a significant difference among genotypes in T2DM group（ P 〈 0. 05 ）. HOMA-IR showed a significant difference among geno- types（P 〈0. 05）in NFG growp.
作者 于晓静 苏本利 王晓梅 金成吉 曲健梅 冯海娟
机构地区 大连大学附属中山医院内分泌科 大连医科大学附属第二医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2007年第10期596-597,共2页 Chinese Journal of Diabetes
关键词 过氧化物酶增殖体激活受体 糖尿病 2型 多态性 Peroxisome proliferator-activated receptor Diabetes mellitus,type 2 Polymorphism
分类号 R587 [医药卫生—内分泌]
  • 相关文献

参考文献7

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二级参考文献9

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共引文献15

同被引文献25

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引证文献1

二级引证文献8

中国糖尿病杂志
2007年 第10期

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