摘要
测定了四氧嘧啶制成的糖尿病小鼠模型骨骼肌的谷氨酰胺-6磷酸果糖转氨酶1(GFAT1)的mRNA表达水平。给予α硫辛酸治疗的糖尿病小鼠,骨骼肌内丙二醛水平低于不予治疗的糖尿病小鼠,而骨骼肌内GFAT-1的mRNA表达水平也低于不治疗组。
The mRNA expression of glutamine ： fructose-6 - phosphate aminotransferase 1 （ GFAT1 ） in the diabetic mouse skeletal muscle was measured. Alloxan-induced diabetic mice were treated with alpha- lipoic acid （LA group）. The malondialdehyde levels in the skeletal muscle were decreased in LAvs DM groups. The expression of GFAT1 mRNA was increased significantly （P 〈 0. 05 ） in DM group. The DM treatment with alpha-lipoic acid significantly decreased GFAT1 expression （P 〈 0. 05）.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2007年第10期630-631,共2页
Chinese Journal of Diabetes
