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单纯疱疹病毒潜伏感染中LAT基因的作用机制 被引量:1

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摘要 单纯疱疹病毒(herpes simplex virus,HSV)属α疱疹病毒科,原发感染生殖器及口面部黏膜上皮组织,引起眼角膜炎、致死性脑炎、生殖器疱疹(genital herpes)等严重影响人类健康的疾病.有Ⅰ型(HSV-1)和Ⅱ型(HSV-2)两个血清型。HSV易传播.嗜神经潜伏,可因多种非特异应激激活,导致症状复发。HSV的潜伏性是有效治疗和彻底清除该病毒的最大障碍。
出处 《实用医学杂志》 CAS 2007年第20期3290-3291,共2页 The Journal of Practical Medicine
基金 国家自然科学基金资助项目(编号:30571668)
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参考文献10

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同被引文献10

  • 1韩建德,张云青,廖绮曼,陈木开,李欢.HSV型特异性糖蛋白抗体检测及其意义[J].中山大学学报(医学科学版),2005,26(2):211-213. 被引量:7
  • 2叶兴东,张锡宝.生殖器疱疹患者无症状HSV排泌研究进展[J].中国皮肤性病学杂志,2005,19(8):500-502. 被引量:3
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  • 6Palliser D, Chowdhury D, Wang QY, et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature, 2006,439: 89-94.
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  • 8Morrissey DV, Lockridge JA, Shaw L, et al. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs. Nat Biotechnol, 2005,23: 1002-1007.
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  • 10杨永林.RNAi的作用机制与抗病毒效应的研究进展[J].国外医学(病毒学分册),2003,10(5):135-138. 被引量:3

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