摘要
目的总结和探讨肝移植术后乙肝复发的预防与处理。方法回顾性分析253例乙肝相关性肝病行肝移植术患者乙肝防治方法、术后乙肝复发的处理。结果术后乙肝复发者7例,复发率2.76%。复发后分别采用加大乙肝免疫球蛋白(HB IG)剂量、改用恩替卡韦、加用贺维力等措施,2例HBsAg经治疗后转阴,2例HBsAg明显下降,总有效率57%。结论肝移植术后HB IG+拉米夫丁能有效预防肝移植术后乙肝复发,HB IG、恩替卡韦、贺维力能不同程度控制肝移植术后乙肝复发。
Objective To study the prevention and treatment of hepatitis B virus recurrence after liver transplantation. Methods Retrospectively analyze the prophylactic strategies and hepatitis B recurrent ratio after liver transplantion. Otherwise to analyze the management of hepatitis B recurrence. Result There are 7 patients diagnosed as hepatitis B recurrence after liver transplantation in 253 patients. HBIG and entecavir and adefovir were used to treat these patients. 2 patients became HbsAg undetectable and HbsAg decreased significantly of 2 patients. The efficiency is 57%. Conclusion HBIG together with lamivudine can prevent hepatitis B re-currence after liver transplantation. HBIG, entecavir or adefovir can be a good choice for the treatment of hepatitis B recurrence.
出处
《肝胆外科杂志》
2007年第5期350-354,共5页
Journal of Hepatobiliary Surgery
关键词
乙肝复发
肝移植
HBIG
恩替卡韦
贺维力
hepatitis B recurrence
liver transplantation
hepatitis B immunoglobulin（HBIG）
entecavir
adefovir
