血管紧张素-(1-7)与动脉粥样硬化

Angiotensin -(1-7) and Atherosclerosis

血管紧张素-(1-7)是AngⅡ的内源性拮抗因子,具有保护血管内皮细胞抗血管平滑肌细胞增殖与迁移等作用,从而发挥抗动脉粥样硬化效应。探讨血管紧张素-(1-7)的生理功能及其在抗动脉粥样硬化中的作用,有助于进一步揭示ACEI及AT1受体阻断剂的抗动脉粥样硬化机制,并有可能为防治动脉粥样硬化等疾病提供新的有效思路。

Angiotensin-（1-7） is an endogenously antagonistic agent of angiotensin II, which has antiatherosclerotic effects by protecting vascular endothelial cells and inhibiting vascular smooth muscle cells proliferation. Investigating the physiological functions and anti-atherosclerotic role of angiotesin （1-7）, which will be helpful to reveal the mechanisms of angiotensin coverting enzyme inhibitor and AT1 receptor antagonist on atherosclerosis, and provide a new and effective method for preventing and treating atherosclerosis.