411例肠易激综合征患者生活质量状况调查

Investigation on the health-related quality of life among 411 patients with irritable bowel syndrome

目的探讨肠易激综合征(IBS)患者的生活质量状况。方法在西安市2所综合医院选取连续的411例IBS患者,其SF-36量表中8个维度的得分以及生理功能总分和心理功能总分与430名健康对照者的得分相比较。结果IBS患者在SF-36量表所有8项维度的得分比健康对照者显著降低(P<0.001),得分最低的维度是总体健康和情感职能,分别为33.5±16.9、40.8±25.1。IBS患者生理功能总分和心理功能总分也显著降低(P<0.001)。结论IBS患者生活质量明显受损。分析结果有助于更好了解IBS对患者功能和健康的影响。

Objective To evaluate and compare the health-related quality of life （HRQOL） on patients with irritable bowel syndrome （IBS）. Methods Following the Rome Ⅲ Criteria,411 IBS patients and 430 healthy people were selected as subjects, who were outpatients in Department of Gastroenterology, 2nd Hospital of Xi＇an Jiaotong University and Shaanxi Provincial People＇s Hospital from July 2006 to April 2007. Using the 36-hem Short-Form Health Survey （SF-36）. This study compared the SF-36 scale scores of IBS patients with the healthy people. Results On all of the 8 SF-36 scales, patients with IBS scored significantly lower than healthy people （P〈 0.001）. Decrements in HRQOL were most predominant in general health perception and role limitations caused by emotional health problem, with scores of 33.5±16.9,40.8 ± 25.1 respectively. The emotional well-being and energy/fatigue scale scores were also quite low （42.2±19.3,43.1 ± 20.2, respectively）. They also scored significantly lower on both physical summary and mental summary scores （P 〈 0. 001）. IBS patients were classified into IBS with constipation, IBS with diarrhea, mixed IBS and unsubtyped IBS subgroups, with percentages as 25.3 %, 50.1%, 11.2 % and 13.4% respectively. Conclusion IBS patients experienced great impairment in HRQOL. These data offered further insight into the impact of IBS on patient functional status and well-being.