杜仲降压方药的半仿生提取工艺研究

Experimental studies on compound Duzhong Jiangya prescription by semi-bionic extraction

目的:优选杜仲降压方药半仿生提取的工艺条件。方法:利用均匀设计法,在药材粒度、煎提温度、煎煮用水量、滤过、浓缩等条件相同的前提下,以桃叶珊瑚苷、水苏碱、熊果酸、黄芩苷、醇浸出物、干浸膏作为考察指标,进行综合评判,优选杜仲降压方药半仿生提取的工艺条件。结果:3煎用水的pH依次为5.8453,7.4961,8.0117,提取总时间3.4180 h。结论:结合生产实际,确定3煎用水的pH依次为6.0,7.5,8.0;提取时间依次为1.5,1.0,1.0 h。

Objective： Optimize the technic condition of Duzhong Jiangya prescription with Semi-bionic Extraction. Method： Using homogeneous design, under the same materials granularity, decoction temperature, consumption of water, filtration, concentra- tion, and taking aucubin, hydrochloric acid stachydrine, maloicacid, baicalin, ethanol extract, dry extract as the indexes, the results were comprehensive considered to optimize the semi-bionic extraction condtions. Result： The optimized SBE extraction conditions are the following： pH values of the water for the thrice extraction is 5. 845 3, 7. 496 1, 8.011 7, and the total extraction time is 3.418 0 h. Conclusion： Considering the fact of manufacture, the SBE extraction conditions are the following： pH values of the water for the thrice extraction is 6.0, 7. 5, 8.0, and the thrice extraction time is 1.5, 1.0, 1.0 h.