水黄皮根抗实验性胃溃疡活性部位的筛选研究

Screening of effective fraction on experimental gastric ulcer from Pongamia pinnata roots

目的:对水黄皮根抗实验性胃溃疡的有效部位进行筛选。方法:采用大鼠无水乙醇胃黏膜损伤模型和小鼠利血平型胃溃疡模型,观察水黄皮根乙醇总提取物和不同极性萃取部位对胃黏膜的影响。结果:水黄皮根乙醇提取物、醋酸乙酯和正丁醇萃取部位都能明显抑制无水乙醇和利血平对胃黏膜的损伤。其对无水乙醇模型的损伤抑制率分别是86.4%,85.4%,11.5%,对利血平模型的溃疡抑制率分别是37.8%,33.8%,19.7%。结论:水黄皮根乙醇提取物、醋酸乙酯和正丁醇萃取物具有明显抗实验性胃溃疡作用,作用最强的部位是醋酸乙酯萃取部位。

Objective： To study the effect of extract from Pongamia pinnata roots on experimental gastric ulcer and screen the effective fraction. Method： The models of gastric mucosa damage were induced by absolute alcohol in rats and reserpine in mice to observed the effect of ethyl alcohol extract from P. pinnata roots （PRE） and different parts on experimental gastric ulcer. Result： PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. In absolute alcohol models the gastric ulcer rates of inhibition were 86. 4%, 85.4%, 11.5%, respectively. In reserpine models the gastric ulcer rates of inhibition were 37. 8%, 33.8%, 19. 7%, respectively. Conclusion： PRE, acetic ether extract and n-butanol extract could significantly inhibit the gastric mucosa damage induced by absolute alcohol in rats and reserpine in mice. Acetic ether extract from P. pinnata roots has the best effection experimental gastric ulcer.