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凋亡抑制基因livin在食管癌中的表达 被引量:3

Expression of livin gene in esophageal cancer
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摘要 目的:探讨凋亡抑制蛋白livin在食管癌组织中的表达及其与食管癌临床病理的相关性。方法:采用RT-PCR结合银染技术检测食管癌组织中livin-α mRNA和livin-β mRNA的表达。结果:36例食管癌组织中livin表达阳性率为50%,其表达与癌组织浸润深度和淋巴结转移有关(P<0.05),而与癌组织分化程度无关(P>0.05)。18例癌旁正常食管组织中livin低表达,阳性率为5.6%,与食管癌组织比较差异十分显著(P<0.01)。结论:livin在食管癌组织中异常表达,有望成为食管癌诊断和基因治疗的新靶点。 Objective:To study the expression of livin in esophageal cancer, and to explore its relationship with the clinical pathology of esophageal cancer. Methods:The expressions of livia-α and livin-β mRNA were detected by reverse transcription polymerase chain reaction combined with silver staining technique in 36 patients with esophageal cancer. Results:The positive expression rate of livin mRNA in the tumor tissues was 50.0%. The expression of livin was correlated with the depth of invasion and lymph node metastasis (P 〈 0.05 ) ,not the histological grade. The positive expression rate of livin in the para-cancerous tissues was 5.6%. Conclusion:Aberrant expression of livin may be a new target for the diagnosis and gene treatment of esophageal cancer.
出处 《中国医科大学学报》 CAS CSCD 北大核心 2007年第5期611-612,615,共3页 Journal of China Medical University
关键词 LIVIN基因 食管癌 逆转录-聚合酶链反应 livin gene esophageal cancer reverse transcription polymerase chain reaction
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