肝硬化患者非O1非O139型霍乱弧菌败血症

Clinical and laboratory characteristics of septicemia in hepatic cirrhosis patients infected by non-O1 non-O139 Vibrio cholerae

目的分析非O1非O139型霍乱弧菌感染的肝硬化败血症患者的临床和实验室特点。方法回顾调查病人的临床基本情况、原发病、实验室结果、治疗和预后;BacT/Alert全自动血培养微生物检测仪培养病人全血标本,用VITEK仪器鉴定细菌。药敏试验根据CLSI(2005)规定,K-B药敏纸片测定法进行。结果3例患者均为肝硬化病人;感染发生在夏季;经左氧氟沙星、加替沙星或联用头孢曲松治疗后痊愈。结论非O1非O139型霍乱弧菌败血症推荐使用头孢三代或氟喹诺酮类抗生素治疗。

Objective To analysis the clinical and laboratory characteristics of sepsis infected in hepatic cirrhosis patients by non-Ol non-O139 Vibrio cholerae（NOVC）. Methods Clinical data of three patients including demographic characteristics, underlying desease, laboratory findings, treatment and clinical outcome were collected in a retrospective survey. Blood cultures of patients were determine by Bact/Alert. Bacteria were identified by VITEK. Disk diffusion method was performed according to guidelines of CLSI （2005） . Results All 3 patients were with hepatic cirrhosis. Infections occurred in summer. NOVC was susceptible to many drugs. The three patients recovered after levofloxacin, gatifloxacin or gatifloxacin and cefiriaxone. Conclusion A third-generation cephalosporin or a fluoroquinolone is recommended for treatment of NOVC septicemia in patients with liver cirrhosis.