Hirsutellide A立体异构体的单晶结构与抗分支杆菌生物活性研究

Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A

研究了hirsutellide A立体异构体的X衍射单晶结构及其抗分支杆菌活性.该化合物具有扭曲马鞍型18元大环结构;在体外生物活性测试中,化合物未表现出明显的抗分支杆菌活性.由实验结果可以看出在天然环酯肽hirsutellide A中3’-C手性中心是其生物活性关键位点之一.

X-ray crystallography and antimycobacterial activity of a cyclohexadepsipeptide, one of the stereoisomers of hirsutellide A, were studied. Its single crystal structure reveals that the 18 membered macrocycle has a distorted saddle shape. The cyclopeptide exhibited no significant antimycobacterial activity in vitro. It was concluded that the chiral center of 3＇-C was one of the pivotal factor in hirsutellide A for its biological activity.