三种常见风湿性疾病患者生活质量分析

The quality of life and its influential factors in patients with 3 major rheumatic diseases

目的探讨三种常见风湿性疾病患者的生活质量(QOL)及其影响因素。方法采用健康状况调查问卷简表-36(SF-36)量表随机对84例系统性红斑狼疮(SLE)、83例类风湿关节炎(RA)和49例强直性脊柱炎(AS)患者进行问卷调查以及临床观察,对其QOL评分、社会心理学因素及疾病活动度等信息进行分析。结果风湿性疾病患者SF-36量表各维度评分均明显低于一般人群(均P<0.01)。影响SLE患者QOL的主要因素包括年龄、SLEDAI评分和疼痛;RA患者QOL综合评分显著低于SLE和AS患者(P<0.05);疼痛、DAS28评分和病程是影响RA患者QOL的主要因素;BASDAI评分和疼痛是AS患者QOL的主要影响因素。上述三种常见风湿性疾病患者的躯体健康影响因素相似,但精神健康影响因素则明显不同。结论风湿性疾病患者QOL水平较一般人群显著降低,其中RA患者QOL的降低程度较为严重;SLE、RA和AS患者QOL的影响因素间存在显著差异性。

Objective To explore the quality of life （QOL） and its influential factors among patients with 3 major rheumatic diseases. Methods A total of 216 patients with rheumatic diseases （84 patients with systemic lupus erythematosus, SLE, 83 with rheumatoid arthritis, RA, and 49 with ankylosing spondylitis, AS） were recruited, The information with regard to their quality of life, sociopsychological factors and the evaluation of disease activity were obtained by using the medical outcomes study short form-36 （SF-36） and clinic documents, Results Patients with rheumatic diseases scored significantly lower with each subscale of SF-36 as compared to those of a healthy population in China （P 〈 0. 01 ）, Patients with RA scored significantly lower with SF-36 than those with SLE and AS, Age, the SLE disease activity index score and pain were the most important factors that affected the QOL of SLE patients and showed negatively correlation with the patients＇ scores with SF-36, so were the DAS28 score, pain and duration of disease for RA patients, The most important factors for QOL of AS patients were the Bath AS disease activity index score and pain, The factors affected the physical health were similar among the three diseases, while the factors correlated with mental health among the three diseases were significantly different. Conclusion The QOL of patients with 3 major rheumatic diseases was significantly lower than those of a health population, The influential factors of QOL were different among the three rheumatic diseases.