老年急性心肌梗死患者血液γ-干扰素水平变化的研究

Study on variation of IFN-γ in serum of senior citizen with acute coronary syndromes

目的探讨老年急性心肌梗死(AMI)患者血清γ-干扰素(IFN-γ)的水平含量与发病关系。方法采用酶联免疫吸附法(ELISA)分别测定34例老年AMI患者、38例老年稳定型心绞痛(SA)患者及39例老年对照组(NC)的血清IFN-γ水平。结果NC组与SA组比较IFN-γ含量差异无统计学意义(P>0.05),而AMI组IFN-γ含量低于NC组及SA组,差异有统计学意义(P<0.001)。结论老年AMI患者IFN-γ水平降低,机体免疫调节失衡,可能对老年AMI的形成和发展产生影响。IFN-γ水平可作为老年AMI严重程度的监测指标。

Objective To evaluate the level of IFN-γ in serum of senior citizen with acute myocardial infarction （AMI） when the disease occurs. Methods The level of IFN-γ in serum of 28 senior citizens with AMI （AMI group） ,38 cases with stable angina（ SA group） and 39 normal controls （NC group） was assayed by ELISA method. Results To compare the level of IFN-γ in NC group with SA group,the improvement was no significant difference （ P 〉0.05）. But the level of IFN-γ in AMI group was less than that in NC group and SA group,the improvement was obvious（ P 〈 0. 1301 ）. Conclusion The level of IFN-γ in serum of senior citizen with AMI is reduced and the immune adjustment in body is unbalance. It may have an effect on the forming and progress of AMI. The level of IFN-γ in serum can serve as an index to detect the serious degree of AMI.