抗精子抗体与不育的相关性研究

Relationship between antisperm antibody and infertility

目的探讨抗精子抗体(AsAb)与不育是否具有相关性,为临床提供诊疗的依据。方法选择186对不育夫妇为不育组,62对已生育的健康夫妇为正常对照组,分别用金标免疫斑点法测定血清中的AsAb。结果不育组丈夫血清中AsAb阳性率高于正常对照组丈夫,差异有统计学意义(χ2=8.492,P=0.004)。不育组妇女血清中AsAb阳性率高于正常对照组妇女,差异有统计学意义(χ2=12.058,P=0.005)。不育组丈夫血清中的AsAb与不育组妻子血清中AsAb有关联性(χ2=8.091,P=0.004)。结论AsAb与不育具有相关性。对不育夫妇进行病因初筛时,有必要检测AsAb,AsAb阳性者要进行治疗。

Objective To investigate the relationship between antibody （AsAb） and infertility, and to prvide some clue for clinic. Methods We select 186 infertile couples as infertile group,and 62 heathy couples as controls. Immunogold-labeling method was used to detect antisperm antibody in serum of the couples. Results The positive rate of antisperm antibody in serum of the infertile husband was significantly higher than that of the control group （ χ^2 = 8. 492, P = 0.004）. The positive rate of antisperm antibody in serum of the infertile wife was significantly higher than that of the control group （ χ^2 = 12. 058, P = 0. 005 ）. The antisperm antibody in serum of the infertile husband was related to that in serum of the infertile wife （ χ^2 = 8.091, P = 0. 004）. Conclusion Antisperm antibody in serum of infertile couples may be related to the pathomechanism of infertility. The detection of AsAb is necessany for preliminary screening of infertile couples.