婴儿维生素D缺乏性佝偻病并外部性脑积水发病机制及预后

Pathogenesis and prognosis of vitamin D-deficient rickets with external hydrocephalus in infants

目的探讨维生素D缺乏性佝偻病并外部性脑积水的发病机制及预后。方法回顾性分析1995年1月～2006年1月新乡医学院第一附属医院73例维生素D缺乏性佝偻病并外部性脑积水患儿的临床资料和随访资料。结果73例维生素D缺乏性佝偻病并外部性脑积水患儿均有不同程度佝偻病表现和颅内高压征象,头颅CT显示蛛网膜下腔增宽。随访观察,发现其中一些患儿存在运动和语言发育迟缓,且随着佝偻病的恢复,上述征象及CT异常征象逐渐消失。结论维生素D缺乏性佝偻病可能是外部性脑积水的一个重要病因,其预后一般良好。

[Objective] To explore the pathogenesis and prognosis of vitamin D-deficient rickets with external hydrocephalus in infants. [Methods] The clinical data of 73 infants with vitamin D-deficient rickets with external hydrocephalus in the First Affiliated Hospital of Xinxiang Medical College from January 1995 to January 2006 were analyzed retrospectively. [Results] 73 infants had the clinical manifestations of various degrees of vitamin-D deficient rickets and high intracranial pressure and broadened subarachnoid cavities in their skull CT scans. The results of the follow-up observation suggested that some of these infants had development retardation of movement and language and these symptoms and abnormal CT findings gradually disappeared after the recovery of vitamin D-deficient rickets. [Conclusions] Vitamin Ddeficient rickets may be an important cause of external hydrocephalus in infants,the prognosis is usually good.