摘要
感音神经性耳聋严重影响了人类健康和生存质量,目前仍无确切有效的治疗方法。随着基因工程技术的发展,基因治疗为攻克这一顽症带来了新希望。基因治疗指将外界正常或治疗基因,通过载体转移到人体的靶细胞,进行基因修饰和表达,从而改善疾病的一种治疗手段。1996年,基因治疗技术首次应用于耳聋的治疗研究,10余年来发展迅速。我们就感音神经性耳聋基因治疗常用的载体、常用的外源基因和载体导入内耳的途径等相关问题综述如下。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2007年第40期2873-2875,共3页
National Medical Journal of China
参考文献34
-
1Luebke AE, Steiger JD, Hodges BL, et al. A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Ther, 2001, 8: 789-794.
-
2罗伟,孙建军,江平,姜伟.豚鼠耳蜗内基因治疗的安全性研究[J].中华医学杂志,2002,82(20):1424-1426. 被引量:7
-
3Stone IM, Lurie DI, Kelley MW, et al. Adeno-associated virusmediated gene transfer to hair cells and support cells of the murine cochlea. Mol Ther, 2005, 11 : 843-848.
-
4Cooper LB, Chan DK, Roediger FC, et al. AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otol Neurotol, 2006, 27: 484-490.
-
5Di Pasquale G, Rzadzinska A, Schneider ME, et al. A novel bovine viruse efficiently transduces inner ear neuroepithelial cells. Mol Ther, 2005, 11 : 849-855.
-
6陈晓巍,李红,曹克利,魏朝刚,金昕.神经营养因子-3和胶质细胞衍生的神经营养因子共转导对小鼠耳蜗螺旋神经节细胞的保护作用[J].中华医学杂志,2003,83(17):1517-1520. 被引量:4
-
7Derby ML, Sena-Esteves M, Breakefield XO, et al. Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors. Hear Res, 1999, 134: 1-8.
-
8时利,董明敏,时文杰,胡吟燕,郭维,翟所强,杨伟炎.碱性成纤维细胞生长因子真核表达载体的构建及其在内耳基因治疗中的实验研究[J].中华耳鼻咽喉科杂志,2003,38(1):21-23. 被引量:4
-
9Oshima K, Shimamura M, Mizuno S, et al. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate heating impairment in rats. FASEB J ,2004, 18: 212-214.
-
10Raphael Y, Frisancho JC, Roessler BJ. Adenoviral-mediated gene transfer into guinea pig cochlear cell in vivo. Neurosei Lett,1996, 207 : 137-141.
二级参考文献31
-
1孙建军,汪吉宝,李桂榕.生长因子对离体听神经元存活与轴突再生的影响[J].中华耳鼻咽喉科杂志,1996,31(5):274-276. 被引量:13
-
2[1]Miller JM,Chi DH,O'keeffe LJ,Kruszka P,Raphael Y,Altschuler RA.Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss.Int J Dev Neurosci,1997,15:631~643.
-
3[2]Ernfors P,Van De Water TR,Loring J,Jaenisch R.Complementary roles of BDNF and NT3 in vestibular and auditory development.Neuron,1995,14:1153~1164.
-
4[3]Chen Q(陈谦),Wang JZ(汪家政),Liu H(刘红),Wu Y(吴燕),Fan M(范明).Construction and characterization of recombinant adenoviruses expressing biologically active human brain-derived neurotrophic factor and neurotrophin-3.Acta Biochim Biophys Sin (生物化学与生物物理学报),2000,32:121~125 ( Chinese,English abstract ).
-
5[4]Komeda M,Roessler BJ,Raphael Y.The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons.Hear Res,1999,131:1~10.
-
6[6]Fritzsch B,Farinas I,Reichardt LF.Lack of neurotrophin 3 cause losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion.J Neurosci,1997,17:6213~6225.
-
7[7]Ylikoski J,Pirvola U,Moshnyakov M,Palgi J,Arumae M.Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear.Hear Res,1993,65:69 ~78.
-
8[8]Fritzsch B,Silos-Santiago I,Bianchi LM,Farinas I.The role of neurotrophic factors in regulating the development of inner ear innervatiion.TINS,1997,120:159 ~164.
-
9[9]Chen Q(陈谦),Wang JZ(汪家政),Liu H(刘红),Wu Y(吴燕),Liu SH(刘淑红),Fan M(范明).Trophic effects of brain-derived neurotrophic factor and neurotrophin-3 mediated by adenovirus to the spiral ganglion neurons.Acta Biophys Sin (生物物理学报),2000,16:511~516 ( Chinese,English abstract).
-
10[10]Akli S,Caillaud C,Vigue E,Strafford-Perricaudet LD,Poenaru L,Perricaudet M,Kahn A,Peschanski MR.Transfer of a foreign gene into the brain using adenovirus vectors.Nat Genet,1993,3:224 ~228.
共引文献24
-
1付勇,龚树生.神经干细胞耳蜗移植与感音神经性耳聋基因治疗[J].中国医学文摘(耳鼻咽喉科学),2004,19(1):14-17.
-
2杜丽,高文元.耳蜗螺旋神经节细胞在声损伤中的改变[J].中国眼耳鼻喉科杂志,2004,4(6):400-402. 被引量:3
-
3潘曦,孙虹.谷氨酸及其受体与耳蜗神经元死亡的关系[J].听力学及言语疾病杂志,2005,13(1):64-66.
-
4徐延军,翟所强.内耳病的基因治疗[J].军医进修学院学报,2005,26(2):155-157.
-
5张鄂,龚树生.干细胞移植在治疗感音性耳聋方面的研究进展[J].国外医学(耳鼻咽喉科学分册),2005,29(6):372-375. 被引量:3
-
6罗伟,孙建军,缪东生,常英展,江平,姜伟.稳态噪声性听神经损伤后耳蜗内人神经营养素-3基因重组腺病毒的表达与观察[J].听力学及言语疾病杂志,2006,14(1):43-44. 被引量:7
-
7韩朝,迟放鲁.腺病毒载体经豚鼠耳蜗中阶导入内淋巴系统的实验观察[J].中国眼耳鼻喉科杂志,2007,7(2):79-81. 被引量:7
-
8杜忆,刘良发,李永新,吴玺宏,李量.细菌性脑膜炎致聋的研究进展[J].中华医学杂志,2007,87(16):1147-1149. 被引量:3
-
9吴建,刘冰,何金,范静平,孙爱华.腺病毒介导的NGF基因转染对爆震性听力损伤耳蜗螺旋神经节细胞的保护作用[J].中华航海医学与高气压医学杂志,2007,14(5):300-302. 被引量:2
-
10孙虹,蒋明,朱晒红.用羟基磷灰石纳米粒作内耳基因治疗新载体的体内外研究[J].中华耳鼻咽喉头颈外科杂志,2008,43(1):51-57. 被引量:16
同被引文献29
-
1Kawamoto K, Izumikawa M, Beyer LA, et al. Spontaneous hair cell regeneration in the mouse utficle following gentamicin ototoxicity. Hear Res, 2009, 247: 17-26.
-
2Albu S, Muresanu DF. Vestibular regeneration-experimental models and clinical implications. J Cell Mol Med, 2012, 16: 1970-1977.
-
3Lalwani AK, Walsh B J, Reilly PG, et al. Development of in vivo gene therapy for hearing disorders: introduction of adenoassociated virus into the cochlea of the guinea pig. Gene Ther, 1996, 3: 588-592.
-
4Okada H, lizuka T, Mochizuki H, et al. Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors. Otol Neurotol, 2012, 33: 655-659.
-
5Luebke AE, Foster PK, Muller CD, et al. Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer. Hum Gene Ther, 2001, 12: 773-781.
-
6Holt JR. Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiol Neurootol, 2002, 7 : 157-160.
-
7Holt JR, Johns DC, Wang S, et al. Functional expression ofexogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J Neurophysiol, 1999, 81: 1881-1888.
-
8Kawamoto K, Oh SH, Kanzaki S, et al. The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice. Mol Ther, 2001,4: 575-585.
-
9Staecker H, Li D, O'Malley BW Jr, et al. Gene expression in the mammalian cochlea: a study of multiple vector systems. Acta Otolaryngol, 2001, 121 : 157-163.
-
10Schlecker C, Praetorius M, Brough DE, et al. Selective atonal gene delivery improves balance function in a mouse model of vestibular disease. Gene Ther, 2011, 18: 884-890.
二级引证文献4
-
1郭婧滢,王国鹏,龚树生.哺乳动物前庭毛细胞损伤与再生的研究进展[J].中华耳鼻咽喉头颈外科杂志,2017,52(1):71-75. 被引量:3
-
2贺璐,龚树生,王国鹏.哺乳动物内耳扁平上皮的研究进展[J].中华耳科学杂志,2019,17(2):253-256. 被引量:2
-
3王国鹏,贺璐,郭婧滢,陈钟壡,龚树生.腺相关病毒Anc80L65转染成年小鼠椭圆囊的实验研究[J].中华耳科学杂志,2022,20(1):21-25. 被引量:1
-
4苏薇,龚树生,王国鹏.内耳毛细胞发育与再生关键转录因子的研究进展[J].中华耳科学杂志,2024,22(3):475-479.
-
1蒋刈,籍灵超,李北成,戴朴,韩东一.基因治疗技术发展在耳聋治疗研究方面的应用[J].中华耳科学杂志,2015,13(4):746-750. 被引量:2
-
2王永宝,刘强和.神经生长因子与老年性耳聋基因治疗研究进展[J].山东医药,2011,51(44):106-107.
-
3苏纪平.感音神经性耳聋的细胞生物学研究现状[J].广西医学,2004,26(1):7-9.
-
4任丽丽,杨仕明.纳米基因载体及其在内耳基因治疗中的研究进展[J].中国听力语言康复科学杂志,2010(3):27-30. 被引量:4
-
5曲雁,王娜.Cx26、Cx30与非综合征耳聋的研究现状及基因治疗的展望[J].中华耳科学杂志,2011,9(1):106-112. 被引量:5
-
6任毅,尹时华.内耳毛细胞再生的基因调控与基因治疗研究进展[J].广西医科大学学报,2009,26(3):489-491.
-
7朱水英,官树雄,唐小艳,周燕飞.慢性鼻窦炎鼻内镜术前脱敏治疗的应用价值研究[J].海南医学院学报,2013,19(3):367-370. 被引量:1
-
8孙虹,吴学文.用于内耳基因治疗的非病毒载体的研究现状与展望[J].临床耳鼻咽喉头颈外科杂志,2013,27(23):1339-1342. 被引量:2
-
9张丽燕,王春云,崔玉芝,李玉莲.环杓关节炎[J].包头医学,2001,25(2):72-73. 被引量:3
-
10王俊,王士礼.感音神经性聋基因治疗[J].国际耳鼻咽喉头颈外科杂志,2006,30(6):385-388.