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感音神经性耳聋基因治疗的新进展 被引量:2

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摘要 感音神经性耳聋严重影响了人类健康和生存质量,目前仍无确切有效的治疗方法。随着基因工程技术的发展,基因治疗为攻克这一顽症带来了新希望。基因治疗指将外界正常或治疗基因,通过载体转移到人体的靶细胞,进行基因修饰和表达,从而改善疾病的一种治疗手段。1996年,基因治疗技术首次应用于耳聋的治疗研究,10余年来发展迅速。我们就感音神经性耳聋基因治疗常用的载体、常用的外源基因和载体导入内耳的途径等相关问题综述如下。
出处 《中华医学杂志》 CAS CSCD 北大核心 2007年第40期2873-2875,共3页 National Medical Journal of China
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参考文献34

  • 1Luebke AE, Steiger JD, Hodges BL, et al. A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function. Gene Ther, 2001, 8: 789-794.
  • 2罗伟,孙建军,江平,姜伟.豚鼠耳蜗内基因治疗的安全性研究[J].中华医学杂志,2002,82(20):1424-1426. 被引量:7
  • 3Stone IM, Lurie DI, Kelley MW, et al. Adeno-associated virusmediated gene transfer to hair cells and support cells of the murine cochlea. Mol Ther, 2005, 11 : 843-848.
  • 4Cooper LB, Chan DK, Roediger FC, et al. AAV-mediated delivery of the caspase inhibitor XIAP protects against cisplatin ototoxicity. Otol Neurotol, 2006, 27: 484-490.
  • 5Di Pasquale G, Rzadzinska A, Schneider ME, et al. A novel bovine viruse efficiently transduces inner ear neuroepithelial cells. Mol Ther, 2005, 11 : 849-855.
  • 6陈晓巍,李红,曹克利,魏朝刚,金昕.神经营养因子-3和胶质细胞衍生的神经营养因子共转导对小鼠耳蜗螺旋神经节细胞的保护作用[J].中华医学杂志,2003,83(17):1517-1520. 被引量:4
  • 7Derby ML, Sena-Esteves M, Breakefield XO, et al. Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors. Hear Res, 1999, 134: 1-8.
  • 8时利,董明敏,时文杰,胡吟燕,郭维,翟所强,杨伟炎.碱性成纤维细胞生长因子真核表达载体的构建及其在内耳基因治疗中的实验研究[J].中华耳鼻咽喉科杂志,2003,38(1):21-23. 被引量:4
  • 9Oshima K, Shimamura M, Mizuno S, et al. Intrathecal injection of HVJ-E containing HGF gene to cerebrospinal fluid can prevent and ameliorate heating impairment in rats. FASEB J ,2004, 18: 212-214.
  • 10Raphael Y, Frisancho JC, Roessler BJ. Adenoviral-mediated gene transfer into guinea pig cochlear cell in vivo. Neurosei Lett,1996, 207 : 137-141.

二级参考文献31

  • 1孙建军,汪吉宝,李桂榕.生长因子对离体听神经元存活与轴突再生的影响[J].中华耳鼻咽喉科杂志,1996,31(5):274-276. 被引量:13
  • 2[1]Miller JM,Chi DH,O'keeffe LJ,Kruszka P,Raphael Y,Altschuler RA.Neurotrophins can enhance spiral ganglion cell survival after inner hair cell loss.Int J Dev Neurosci,1997,15:631~643.
  • 3[2]Ernfors P,Van De Water TR,Loring J,Jaenisch R.Complementary roles of BDNF and NT3 in vestibular and auditory development.Neuron,1995,14:1153~1164.
  • 4[3]Chen Q(陈谦),Wang JZ(汪家政),Liu H(刘红),Wu Y(吴燕),Fan M(范明).Construction and characterization of recombinant adenoviruses expressing biologically active human brain-derived neurotrophic factor and neurotrophin-3.Acta Biochim Biophys Sin (生物化学与生物物理学报),2000,32:121~125 ( Chinese,English abstract ).
  • 5[4]Komeda M,Roessler BJ,Raphael Y.The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons.Hear Res,1999,131:1~10.
  • 6[6]Fritzsch B,Farinas I,Reichardt LF.Lack of neurotrophin 3 cause losses of both classes of spiral ganglion neurons in the cochlea in a region-specific fashion.J Neurosci,1997,17:6213~6225.
  • 7[7]Ylikoski J,Pirvola U,Moshnyakov M,Palgi J,Arumae M.Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear.Hear Res,1993,65:69 ~78.
  • 8[8]Fritzsch B,Silos-Santiago I,Bianchi LM,Farinas I.The role of neurotrophic factors in regulating the development of inner ear innervatiion.TINS,1997,120:159 ~164.
  • 9[9]Chen Q(陈谦),Wang JZ(汪家政),Liu H(刘红),Wu Y(吴燕),Liu SH(刘淑红),Fan M(范明).Trophic effects of brain-derived neurotrophic factor and neurotrophin-3 mediated by adenovirus to the spiral ganglion neurons.Acta Biophys Sin (生物物理学报),2000,16:511~516 ( Chinese,English abstract).
  • 10[10]Akli S,Caillaud C,Vigue E,Strafford-Perricaudet LD,Poenaru L,Perricaudet M,Kahn A,Peschanski MR.Transfer of a foreign gene into the brain using adenovirus vectors.Nat Genet,1993,3:224 ~228.

共引文献24

同被引文献29

  • 1Kawamoto K, Izumikawa M, Beyer LA, et al. Spontaneous hair cell regeneration in the mouse utficle following gentamicin ototoxicity. Hear Res, 2009, 247: 17-26.
  • 2Albu S, Muresanu DF. Vestibular regeneration-experimental models and clinical implications. J Cell Mol Med, 2012, 16: 1970-1977.
  • 3Lalwani AK, Walsh B J, Reilly PG, et al. Development of in vivo gene therapy for hearing disorders: introduction of adenoassociated virus into the cochlea of the guinea pig. Gene Ther, 1996, 3: 588-592.
  • 4Okada H, lizuka T, Mochizuki H, et al. Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors. Otol Neurotol, 2012, 33: 655-659.
  • 5Luebke AE, Foster PK, Muller CD, et al. Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer. Hum Gene Ther, 2001, 12: 773-781.
  • 6Holt JR. Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiol Neurootol, 2002, 7 : 157-160.
  • 7Holt JR, Johns DC, Wang S, et al. Functional expression ofexogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J Neurophysiol, 1999, 81: 1881-1888.
  • 8Kawamoto K, Oh SH, Kanzaki S, et al. The functional and structural outcome of inner ear gene transfer via the vestibular and cochlear fluids in mice. Mol Ther, 2001,4: 575-585.
  • 9Staecker H, Li D, O'Malley BW Jr, et al. Gene expression in the mammalian cochlea: a study of multiple vector systems. Acta Otolaryngol, 2001, 121 : 157-163.
  • 10Schlecker C, Praetorius M, Brough DE, et al. Selective atonal gene delivery improves balance function in a mouse model of vestibular disease. Gene Ther, 2011, 18: 884-890.

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