脑血管病急性期患者血清脂质过氧化物、谷胱甘肽过氧化物酶和超氧化物歧化酶的检测及其临床意义的研究

Detection of Serum LPO,GSH-PX and SOD in Patients with Acute Cerebrovascular Disease and Its Significance

目的探讨血清脂质过氧化物(LPO)、谷胱甘肽过氧化物酶(GSH-PX)和超氧化物歧化酶(SOD)在脑血管病急性期的变化及其作用。方法以生物学方法检测44例脑血管病急性期患者血清中脂质过氧化物、谷胱甘肽过氧化物酶和超氧化物歧化酶含量。结果脑血管病患者发病后6h内血清LPO即明显升高,血清GSH-PX、SOD明显下降:6～24h这三项指标的变化更大;24～72h血清SOD继续下降,而血清GSH-PX略有回升,血清LPO略有降低。与对照组比较有显著性差异(P<0.01,P<0.05),发病三天内脑梗死组患者血清SOD、GSH-PX较脑出血组患者明显低,血清LPO较脑出血组患者明显高,与对照组比较均有显著性差异(P<0.01),发病时间相近脑梗死组患者与脑出血组患者比较结果亦相同。结论应用自由基清除剂治疗脑血管病时应尽早进行,最好能在6h内,才有可能取得满意的治疗效果。

Objective To investigate the role of serum lipid peroxide（LPO）,glutathione peroxidase（GSH-PX） and superoxide dismutase（SOD）.Methods The levels of serum LPO,GSH-PX and SOD in 44 patients with acute cerebrovascular disease were determined by biochemistry methods.Results The level of serum LPO rose signifi-cantly in 6 hours after the onset of cerebrovascular diseases in contrast with the decrease of serum GSH-PX and SOD.In 6 to 24 hours the changes of these values were more obvious.In 24 to 72 hours serum SOD and LPO decreased,but serum GSH-PX increased appreciably.All these changes were significant compared with the control groups（P〈0.01,P〈0.05）.In the first three days after the onset of cerebral infarction,serum SOD,GSH-PX were lower and serum LPO was higher than in the patients of cerebral hemorrhage.Conclusion It recommends that using free radical scavenger to treat the cerebrovascular diseases is more effective in 6 hours after the onset.