恶性肿瘤患者化疗后感染的临床分析及治疗

The clinical analysis and treatment of the infection in patients with malignant tumour after chemotherapy

目的探讨化疗后恶性肿瘤患者感染因素分析,为临床合理用药提供依据。方法回顾性分析了我院近5年56例化疗后发生感染的肿瘤病人资料。结果恶性肿瘤患者感染的好发部位为呼吸道、消化道、泌尿道、血液等,导致感染病原菌以革兰氏阴性菌为主,占61.5%,感染病原菌依次为绿脓杆菌、克雷伯菌、大肠埃希菌、表皮葡萄球菌、金黄色葡萄球菌及真菌等。结论恶性肿瘤患者化疗感染时,在应用强有力广谱抗生素药物治疗同时,应防止患者合并真菌感染,应用粒细胞集落刺激因子促进白细胞恢复,加强支持治疗。

Objectlve To investigate the clinical data of hospital acquired infection in patients with malignant tumour undergoing chemotherapy for the rational use of antibiotics. Methods Clinical data of 56 patients with malignant tumour after receiving chemotherapy in hospital were analysed restrospectively. Results The respiratory tract was the most frequent infection site followed by gastric tract, urinary tract and blood. The most common pathegens isolated were E . coli,klebsiella spp. Sepidermidis, saureus and fungi. Conclusions When the patients with malignant tumour after chemotherapy occurred infection, antimicrobial agents and antifungal should be given to prevent infection, granulocyte colony stimulating factors can be applied to promote the recovery of leukocytes, supportive treatment should be strengthened.