生长激素缺乏症患儿脂代谢的临床研究(附41例分析)

Clinical study of lipid metabolism in children with growth hormone deficiency

目的探讨生长激素缺乏症(GHD)患儿的脂代谢变化情况及其临床意义。方法41例GHD患儿(观察组)均测量体质量指数(BMI)、血压,测定血三酰甘油(TG)、总胆固醇(TC),行肝脏B超检查。选取50名健康儿童作对照。结果观察组与对照组BMI分别为(17.8±2.5)kg/m2、(16.4±2.3)kg/m2,血TG分别为(1.32±0.53)mmol/L、(1.01±0.81)mmol/L,血TC分别为(4.9±0.7)mmol/L、(4.1±0.5)mmol/L,两组比较差异均有统计学意义(P值分别为<0.01,<0.05,<0.01)。两组血压值差异无统计学意义(P>0.05)。观察组与对照组高脂血症检出率分别为24.4%和0%,脂肪肝检出率分别为14.6%和0%,观察组高脂血症和脂肪肝的检出率均高于对照组(P<0.01和P<0.05)。结论GHD患儿存在脂代谢紊乱,可能导致成年后患心血管疾病及肝硬化的风险增大。

Objective To study the changes of lipid metabolism in the children with growth hormone deficiency （GHD） and the clinical significances of the changes. Methods Forty-one eases with GHD were chosen in the patient group. Their body mass index （BMI） and blood pressure were measured. Their plasma triglyceride （TG）, total cholesterol （TC） were detected. They also received liver ultrasound examination. Fifty healthy controls were measured at the same time. Results There were significant differences of BMI [ （17. 8±2.5） vs （16.4±2. 3） kg/m^2, P〈0. 01], plasma TG [ （1.32 ± 0. 53） vs （1.01± 0. 81） mmol/L, P〈0. 05] and plasma TC [ （4. 9±0. 7） vs （4. 1±0. 5） rnmol/L, P〈0.01] between the patient group and the control group. The incidences of hyperlipidemia and fatty liver disease were significantly higher in the patient group than those in the control group [24. 4% vs 0%, P〈0. 01; 14. 6% vs 0%, P〈0.05] . There was no significant difference of blood pressure between the two groups. Conclusion The lipid metabolism is abnormal in the children with GHD and it may increase the risk of cardiovascular disease and cirrhosis of liver in their adulthood.