乳腺癌组织中P33^(ING1)蛋白的表达及临床意义

The expression of P33^(ING1) protein in breast carcinoma and its clinical significance

目的探讨抑癌基因P33^(ING1)蛋白表达与乳腺癌发生、发展的关系。方法用S-P免疫组织化学法检测90例乳腺癌标本中P33^(ING1)蛋白的表达。结果P33^(ING1)蛋白在乳腺癌组织中表达的阳性率为38.89%(35/90),在癌旁组织为75.56%(68/90),两者比较差异有高度显著性(P<0.01)。P33^(ING1)蛋白的低表达与肿瘤大小、腋窝淋巴结转移数目有明显关系(P<0.05或0.01),与年龄、病理类型和病理分级无明显关系。结论P33^(ING1)基因是一个抑癌基因,它的低表达与乳腺癌的发生、发展有密切关系。

Objective To explore the relationship between P33^INC1 protein expression and occurrence and progress of breast carcinoma. Methods The expression of P33^INC1 protein expression in 90 samples of breast carcinoma was studied by S-P immuno - histochemical technique. Results The positive rate of P33^INC1 protein expression in 90 samples of breast cancerous tissues was 38.89% （35/90）, and 75.56% （68/90）in the adjacent breast tissues. There was statistically significant difference between them （ P 〈 0.01）. The low expression of P33^INC1 protein is significantly related with tumor size and the number of metastatic lymph nodes（ P 〈 0.05 or 0.01）, but had no relation with age, pathological type and pathological grade. low expression is significantly related with the occurrence and Conclusion P33^INC1 gene is an anticancer gene, its progress of breast carcinoma.