正交设计法优选白术的浸润与切制工艺

Optimum Selection Processing Study of Rhizoma Atractylodis Macrocephalae soaked and cut by Orthogonal Design

目的探讨白术的最佳浸润与切制工艺。方法以水溶性浸出物含量、醇溶性浸出物含量、白术内酯Ⅲ为指标,选择溶剂用量、浸润时间、饮片厚度3个因素,用L9(34)正交设计表,采用综合加权评分法,对上述三因素进行炮制工艺的优选。结果白术的最佳浸润与切制工艺为:加0.6倍量的溶剂,浸润20h,饮片厚度为3mm。结论为进一步规范白术的浸润与切制工艺提供了参考依据。

OBJECTIVE To research the best processing method of Rhizoma Atractylodis Macrocephalae soaked and cut. METHODS 1.9（34） orthogonal table are decided with three factors：The amount of solvent, thickness of pieces, soaking time. According to the amount of water-soluble extractive,alcohol-soluble extractive and Atractylenolide Ⅲ, orthogonal design is applied to processing. RESULTS The best process is..the thickness of piece is 3mm,the amount of solvent is 0. 6 times and soaking for 20h. CONCLUSION The results can provide basis for establishing the quality standard of this crude drug.