复合明胶涂层对钙磷陶瓷多孔支架的增强作用

Calcium phosphate porous ceramic scaffolds reinforced by composite gelatin coating

采用有机泡沫浸渍工艺制备了高孔隙率的钙磷多孔陶瓷支架,将多孔陶瓷样品浸于明胶溶液中渗涂得到陶瓷/明胶复合支架;采用复合明胶涂层的方法对钙磷多孔陶瓷支架进行增强处理,在不破坏多孔支架孔隙特征的情况下,成功地在样品的孔壁上复合了明胶涂层。复合明胶涂层提高了样品的压缩强度和压缩模量,与未涂覆样品相比,涂敷样品受压时的应变特性发生了明显变化。尤其是渗涂5%明胶溶液的多孔样品,在保持高孔隙率(82.8%)的条件下其压缩强度和压缩模量分别由原来的1.04 MPa和0.105 GPa增加到5.17 MPa和0.325GPa。研究结果表明,孔壁上复合明胶涂层可以有效地增强多孔陶瓷支架。

The calcium phosphate porous ceramic scaffolds with high porosity for the bone tissue engineering were fabricated by the foam impregnation technology, and the composite scaffolds composed of ceramic and gelatin were gained by coating the porous ceramic samples with gelatin solution. It was found that gelatin coatings were formed on the pore walls of porous scaffold samples successfully without destroying their porous characteristic, but these coatings improved the compressive strength and compressive modulus of the samples. The scaffolds, coated with gelatin, were characterized by their nonlinear fractural behavior under compressive loading. Especially, the com- pressive strength value and the compressive modulus value of porous samples coated with 5 % gelatin solution were improved from -1.04 MPa and -0. 105 GPa to 5. 17 MPa and 0. 325 GPa respectively with the high porosity （82. 8%） maintained. The results indicate that the gelatin coatings on the surface of pores reinforce the porous ceramic scaffolds effectively.