急性肺栓塞患者肺功能改变的研究

The Changes of Lung Function in Patients with Acute Pulmonary Thrombosis Embolism.

肺栓塞发生时，各种栓子阻塞肺动脉系统后，肺动脉的血流被完全或部分阻塞，发生一系列的病理生理改变，血液动力学和呼吸功能出现不同程度的改变。已有大量的动物及临床试验对栓塞后动脉血气的变化进行了研究，而少有对呼吸功能改变的临床研究。本文旨在探讨肺栓塞后患者肺功能的改变，以期对肺栓塞的病理生理学改变有进一步的认识。

Objective Studying the change of lung function in patients with acute pulmonary thrombosis embolism （PTE）.Methods 25 patients with PTE underwent the study, 14 male and 11 femal, with an age of （47.5 ±9.8） years, who had clearly diagnosis, were treated by heparinize for 5- 10days. The control group had 30 healthy volunteers, 16 male and 14 female, with an age of （42.7±10.5） years. Spirometry was performed in the sit position. The quantities： vital capacity（VC）, forced vital capacity（FVC）, forced expiratory volume in one second （FEVL）, residual volume（RV）, retio of residual volume to total lung capacity（RV/TLC）, and diffusing capacity of the lung for carbon monoxide（DLCO） were measured in two groups. Results （1） 12 cases（48%） had restrictively impaired pulmonary function, 5 cases（20%） had obstructively impaired pulmonary function, 6 cases（24%） had mixed impaired pulmonary function, 2 cases（8%）had normal pulmonary function. （2） 8 cases＇ RV were reduced, their TLC were in the normal volume. （3） 10 cases had different damage in DLCO. Conclusion Because of difference of the patholo physiological changes, the patients with acute pulmonary thrombosis embolism had different changes in lung function.