脉冲辐解研究 DNA 羟基加成自由基快速修复过程

PULSE RADIOLYSIS STUDIES OF THE INTERACTION OF HYDROXYCINNAMIC ACID DERIVATIVES WITH OXIDIZING OH ADDUCTS OF DNA

脉冲辐解研究ＤＮＡ羟基加成自由基快速修复过程⒇姜岳姚思德林念芸（中国科学院辐射化学开放研究实验室中国科学院上海原子核研究所上海２０１８００）氧自由基由于具有极其活泼的化学活性和致癌、致心血管疾病、感染及促进衰老等作用而引起人们的广泛关注。而羟自由基氧...

Using a pulse radiolytic technique, it has been demonstrated that the interaction of oxidizing OH adducts of DNA with hydroxycinnamic acid derivatives proceeds via an electron transfer process with rate constant of (5～7)×10 8 dm 3 mol -1 s -1 .Besides, the rate for fast repair of OH adducts of dAMP and DNA (ssDNA anddsDNA) are slower than the corresponding rate for the rest OH adducts of DNA constituents. The slower rate for oxidizing OH adduct of dAMP and DNA has indicated that repair of oxidizing OH adduct of dAMP may be the rate determining process during the interaction of hydroxycinnamic acid derivatives with OH adduct of DNAcontaining the varieties of OH adducts of DNA constituents.