新生儿窒息后心肌损害与心肌肌钙蛋白I关系的临床研究

Clinical researches on the relation of cardiac troponin I and myocardial damage in asphyxia neonatal

目的探讨血清心肌肌钙蛋白I(CTn-I)测定在评估新生儿窒息后心肌损害中的临床价值。方法采用免疫发光法和酶动力法对60例窒息新生儿和30例正常新生儿生后24h、3d、7d进行血清CTn-I及肌酸磷酸激酶心型同功酶(CK-MB)检测。结果窒息组急性期血清CTn-I、CK-MB浓度均明显高于对照组(P<0.01);轻度窒息组与重度窒息组患儿血清CTn-I浓度比较差异有显著性意义,重度窒息组7d后血清CTn-I浓度仍升高,而轻重窒息组CK-MB浓度在3d后比较差异无显著性意义,7d后均降至正常。结论CTn-I水平与窒息程度呈正相关,且特异性优于CK-MB,可作为诊断心肌损害,评价疗效,预后不良的可靠指标。

Objective To investigate the clinical value of sernmal cardiac troponin I （CTn-I）in determining yocardial damage in asphyxial newborn infants. Methods Levels of sernmal cardiac troponin I （CTn - I）and creatine kinase-MB isoenzyme （CK-MB）. were measured by radioimmnuoassay and enzyme dynamic method at 24h, 3d and 7days newborns （60 cases with neonatal asphyxia and 30 normal infants served as control group.Results The levels of serumal（CTn -I）and CK-MB in asphyxia neonatal were significant higher than control group （P〈0.01）;the Sernmal （CTn - I） has significant difference between the mild asphyxia group and severe asphyxia group,The levels of CTn-I were still higher after 7 days with severe asphyxia;But the level of（CK-MB） has no significant difference between the mild and severe asphyxia group after 3days,They both returned to normal after 7 days.Conclusion CTn-I level were positively correlated with degree af asphyxia＇ , its specificity is better than CK-MB, It can be used as reliable indicator.of diagnostic. myocardial damage, evaluate efficacy and poor prognosis.