燃煤型地氟病非骨相早期诊断敏感指标初探

APPROACH OF EARLY DIAGNOSTIC SENSITIVE INDEXES FROM NONSKELETAL PHASE IN THE ENDEMICAL FLUOROSIS FROM BURNING COAL

本研究通过对燃煤型地氟病区和非病区的现场流行病学配对调查,同步收集有关环境氟浓度等6大类指标,数据经微机处理,建立了此型氟中毒非骨相早期诊断敏感指标体系。研究发现,在28个指标组成的定量指标子系中,有82.14％的指标为敏感(P<0.05)或高度敏感(P<0.02～P<0.001)。其中新增的骨关节运动功能测量指标中,XI4(右肘伸)这一指标能非常敏感而又客观地反映此类氟中毒患者肘部关节伸展运动功能的障碍和损害状况。在9个定性指标子系中,有7个指标敏感,显著差异(P<0.05)或极显著差异(P<0.01～P<0.001)。建议燃煤氟污染病区结合现有条件,将这些指标选用于实际工作之中。

During the epidemical survey for the worksite in the endemical fluorosis from the burning coal,the human data about the fluoride sources of environment, living conditions, load capacity of fluoride in the body, clinical symptoms and signs, the motional functions of skeleton and joints, as well as the biochemistry and enzymes in serum and urine was collected. After the student'test and chi-square test with matched-pair,the quatitative and quality indexes were sorted by the size of P value. The index out of 82. 14% is sensitive(P<0. 05) or highly sensitive(P< 0. 02 - P<0. 001)among the 28 quatitative indexes. The index out of 77. 78% is sensitive(P< 0. 05)(P<0. 01-P<0. 001 )among the 9 quality indexes . It was suggested that the sub-series of quatitative indexes and quality indexes could be practically used in the district of the endemical fluorosis for early diagnosis.