摘要
MicroRNAs(miRNAs)were first described in 1993 by Lee and col eagues,and the term microRNA was only introduced in 2001 in a set of three articles in Science[1].One of the biggest surprises in the past few years has been the emergence of miRNAs as a major new class of gene expression regulators.Recent studies suggest that miRNA alterations are involved in the initiation and progression of human cancer.The brain tumor, glioblastoma multiforme,is the most malignant and deadly form of gliomas. The prognosis is poor and the median survival with combined radiotherapy and chemotherapy is only 14.6 months.With the discovery of miRNA,the miRNA profiles may become useful biomarkers for brain tumor diagnostics, and miRNA therapy could be a powerful tool for brain tumor prevention and therapeutics.This review outlines the background of miRNA and its expression and therapeutic potential for brain tumors.
MicroRNAs （miRNAs） were first described in 1993 by Lee and colleagues, and the term microRNA was only introduced in 2001 in a set of three articles in Science. One of the biggest surprises in the past few years has been the emergence of miRNAs as a major new class of gene expression regulators. Recent studies suggest that miRNA alterations are involved in the initiation and progression of human cancer. The brain tumor, glioblastoma multiforme, is the most malignant and deadly form of gliomas. The prognosis is poor and the median survival with combined radiotherapy and chemotherapy is only 14.6 months. With the discovery of miRNA, the miRNA profiles may become useful biomarkers for brain tumor diagnostics, and miRNA therapy could be a powerful tool for brain tumor prevention and therapeutics. This review outlines the background of miRNA and its expression and therapeutic potential for brain tumors.
基金
the grants fromthe National Natural Science Foundation ofChina(No.30772231)
Tianjin Natural Sci-ence Foundation(No.05YFJZJC1002).
关键词
癌症
治疗方法
RNA
转换模式
miRNA, post-transcript regulation, tumorigenesis, cancer, glioblastoma
